Table 3 Diagnostic accuracy of TB-related symptoms with and without urine LAM testing for diagnosing culture-confirmed pulmonary tuberculosis by CD4 count ≥ and <100 cell/mm3
Sensitivity | Specificity | Negative PV | ||||||
|---|---|---|---|---|---|---|---|---|
Positive/Total | % (95% CI) | p-value | Negative/Total | % (95% CI) | p-value | % (95% CI) | p-value | |
Cough | 0.35 | 0.005 | <0.0001 | |||||
CD4 ≥ 100 cells/mm3 | 25/52 | 48 (34–62) | 270/385 | 70 (65–75) | --- | 91 (87–94) | --- | |
CD4 < 100 cells/mm3 | 41/71 | 58 (45–69) | 106/167 | 63 (56–71) | --- | 78 (70–85) | --- | |
Cough or Urine LAM Positive | 0.24 | 0.007 | 0.0002 | |||||
CD4 ≥ 100 cells/mm3 | 32/52 | 62 (47–75) | --- | 255/385 | 66 (61–71) | --- | 93 (90–96) | --- |
CD4 < 100 cells/mm3 | 52/71 | 73 (61–83) | --- | 98/167 | 59 (51–66) | --- | 84 (76–90) | --- |
Any TB-related Symptoma | 0.05 | <0.0001 | 0.0007 | |||||
CD4 ≥ 100 cells/mm3 | 35/52 | 67 (53–80) | --- | 168/385 | 44 (39–49) | --- | 91 (86–95) | --- |
CD4 < 100 cells/mm3 | 60/71 | 85 (74–92) | --- | 54/167 | 32 (25–40) | --- | 83 (72–91) | --- |
Any TB-related Symptoma or Urine LAM Positive | 0.09 | <0.0001 | 0.004 | |||||
CD4 ≥ 100 cells/mm3 | 39/52 | 75 (61–86) | --- | 159/385 | 41 (36–46) | --- | 92 (87–96) | --- |
CD4 < 100 cells/mm3 | 63/71 | 89 (79–95) | --- | 52/167 | 31 (24–39) | --- | 87 (75–94) | --- |
Any TB-related Symptoma or Abnormal chest x-ray | 0.03 | <0.0001 | 0.007 | |||||
CD4 ≥ 100 cells/mm3 | 38/52 | 73 (59–84) | --- | 168/385 | 44 (39–49) | --- | 92 (88–96) | --- |
CD4 < 100 cells/mm3 | 64/71 | 90 (81–96) | --- | 51/167 | 31 (24–38) | --- | 88 (77–95) | --- |
Any TB-related Symptoma or Abnormal chest x-ray or Urine LAM Positive | 0.06 | <0.0001 | 0.03 | |||||
CD4 ≥ 100 cells/mm3 | 41/52 | 79 (65–89) | --- | 159/385 | 41 (36–46) | --- | 94 (89–97) | --- |
CD4 < 100 cells/mm3 | 66/71 | 93 (84–98) | --- | 49/167 | 29 (23–37) | --- | 91 (80–97) | --- |