Assessment of serology and spirometry and the combination of both to complement microbiological isolation for earlier detection of Pseudomonas aeruginosa infection in children with cystic fibrosis

Table 2 Comparison of the area under the curve, sensitivity, specificity, positive and negative predictive values between serology, spirometry and the combination of serology and spirometry for prediction of P. aeruginosa infection

Diagnostic test	AUC	Sensitivity	Specificity	PPV	NPV	Number of visits
Serology	0.81 (SE 0.03, P < 0.02, CI 0.74–0.88)	0.80	0.67	0.39	0.93	N = 242
Spirometry	0.61 (SE 0.05, P < 0.05, CI 0.52–0.70)	0.29	0.83	0.43	0.71	N = 177
Serology and spirometry	0.70 (SE 0.04, P < 0.02, CI 0.61–0.78	0.28	0.90	0.46	0.79	N = 177

Legend: AUC Area under the curve, SE Standard error, CI – 95% confidence interval, NPV Negative predictive value, PPV Positive predictive value, N Number of visits

ISSN: 1471-2466