Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study

Table 3 Independent predictors of incident resting hypoxemia in individuals with COPD

Variable	OR	95% CI	P-value
Enrollment at Denver clinical site	8.30	3.05–22.6	<0.001
Baseline oxygen saturation, %	0.70	0.58–0.85	<0.001
Congestive heart failure	6.92	1.56–30.6	0.01
PA/A ratio >1	2.81	1.17–6.74	0.02
Severe AECOPD within 12-months	3.31	1.38–7.90	0.007

Variables included in the backwards multivariate logistic regression model: age, race, sex, Denver, baseline oxygen saturation, pack-year history of tobacco use, congestive heart failure, hypertension, asthma, sleep apnea, gastroesophageal reflux disease, FEV₁ percent predicted, percent emphysema, percent gas trapping, PA/A > 1, severe AECOPD within 12-months of visit (R² = 0.39, P < 0.001). Abbreviations: OR = odds ratio, CI = confidence interval, PA/A = pulmonary artery to aorta ratio, AECOPD = acute exacerbation of chronic obstructive pulmonary disease

ISSN: 1471-2466