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Table 2 Independent predictors of chronic and mucoid Pa infection

From: Change in Pseudomonas aeruginosa prevalence in cystic fibrosis adults over time

 

Chronic Pa

Mucoid Pa

OR (95%CI)

OR (95%CI)

Univariate

 Age (yr)

0.83 (0.63–1.10)

0.82 (0.66–1.02)

 Diagnosis

  Age (yr)

0.96 (0.94–0.98)

0.97 (0.96–0.99)

  Diagnosis after 25 years of age

0.12 (0.04–0.31)

0.21 (0.09–0.46)

 Gender, female

1.07 (0.65–1.77)

0.94 (0.61–1.44)

 CFTR functiona

1.94 (1.10–3.44)

2.61 (1.28–5.63)

 CF-related diabetesb

1.02 (0.63–1.65)

0.88 (0.57–1.34)

 Pancreatic insufficiencyc

2.21 (1.11–4.37)

2.52 (1.46–4.38)

 Lung Functiond

0.90 (0.82–1.00)

0.79 (0.71–0.88)

Multivariablee

 Age (yr)

1.03 (0.99–1.08)

1.00 (0.97–1.03)

 Diagnosis

  Age (yr)

0.96 (0.91–1.02)

1.01 (0.97–1.05)

  Diagnosis after 25 years of age

0.18 (0.03–1.20)

0.21 (0.05-0.95)

 CFTR functiona

0.51 (0.17–1.55)

0.99 (0.42-2.34)

 Pancreatic insufficiencyc

1.23 (0.53–2.82)

1.58 (0.89–2.80)

 Lung Functiond

0.91 (0.82–1.01)

0.84 (0.77–0.92)

  1. aComparator group: Residual CFTR function: at least one allele containing mutation resulting in partial CFTR function (Class 4 or 5)
  2. bCF-related diabetes: use of insulin
  3. cPancreatic insufficiency: use of pancreatic enzymes
  4. d10% difference in percent predicted FEV1
  5. eVariables with significance level ≤ 0.1 included in multivariable analysis