Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome

BMC Pulmonary Medicine

Table 1 Results of fitting the model to ARDS patient data of PaO₂ and PaCO₂

		Moderate ARDS, High CO [25]		Moderate ARDS, Normal CO [26]		Severe ARDS, High CO [27]
Parameters obtained from data	CO (l min⁻¹)	8		4.09		7.3
	F_IO₂	0.5		0.45		1
	Vt (ml kg⁻¹)	12		10		10
	PEEP (cm H₂O)	0		0		0
Parameters determined by optimization^a	VR (b min⁻¹)	12		10		10
	Duty Cycle	0.33		0.35		0.46
	RQ	0.9		0.9		0.7
	VO₂ (ml min⁻¹)	307		303		306
	Hb (g dl⁻¹)	9.9		14.5		10.5
		Data	Model	Data	Model	Data	Model
Results of fitting the model to the data	PaO₂ (kpa)	10.6	11.2	10	10.8	6.6	7.5
Results of fitting the model to the data	PaCO₂ (kpa)	5	4.4	5.3	5.2	3.7	4.3
Other results	PvO₂ (kpa)	NA	4.6	NA	4.4	NA	4.1
Other results	Shunt Fraction (%)	NA	22	NA	16	NA	44

List of Abbreviations CO cardiac output, FiO ₂ fraction of O₂ in inspired gas, Vt tidal volume, VR ventilator rate, PEEP positive end expiratory pressure, IE inspiratory to expiratory ratio, RQ respiratory quotient, VO ₂ oxygen consumption, TOP threshold opening pressure, S alveolar stiffness factor, Pext extrinsic pressure, Hb hemoglobin in blood, PaO ₂ arterial oxygen tension, PaCO ₂ arterial carbon dioxide tension, PvO ₂ mixed venous oxygen tension, shunt fraction
^aOptimization methodology and parameter ranges given in Additional file 1

ISSN: 1471-2466