Table 3 Adjusted Change From Baseline in Hemodynamic Parameters at Week 12
Baseline Characteristic | Sildenafil Dose, TID | ||
|---|---|---|---|
1 mg | 5 mg | 20 mg | |
Heart rate | |||
n | 33 | 32 | 33 |
LS mean (95% CI), bpm | 3.4 (–1.1 to 7.9) | −0.7 (–5.2 to 3.7) | −5.0 (–9.3 to –0.8) |
P value vs 20 mg TID | 0.0019 | 0.1066 | — |
RAP | |||
n | 33 | 33 | 34 |
LS mean (95% CI), mmHg | −0.5 (–2.3 to 1.2) | −0.8 (–2.5 to 0.9) | −1.7 (–3.3 to 0) |
P value vs 20 mg TID | 0.2741 | 0.4098 | — |
mPAP | |||
n | 33 | 33 | 34 |
LS mean (95% CI), mmHg | −0.1 (–4.0 to 3.7) | −2.2 (–5.9 to 1.5) | −2.6 (–6.2 to 0.9) |
P value vs 20 mg TID | 0.2776 | 0.8458 | — |
Cardiac index | |||
n | 32 | 31 | 30 |
LS mean (95% CI), L/min/m2 | 0.1 (–0.2 to 0.3) | 0.1 (–0.1 to 0.4) | 0.1 (–0.2 to 0.3) |
P value vs 20 mg TID | 0.9023 | 0.7590 | — |
PVR | |||
n | 32 | 31 | 30 |
LS mean (95% CI), Wood units | −1.2 (–3.3 to 0.9) | −2.0 (–4.1 to 0) | −2.4 (–4.3 to –0.4) |
P value vs 20 mg TID | 0.3694 | 0.8010 | — |
PVRI | |||
n | 32 | 31 | 30 |
LS mean (95% CI), Wood units*m2 | −1.7 (–4.9 to 1.5) | −3.1 (–6.2 to 0) | −3.5 (–6.4 to –0.5) |
P value vs 20 mg TID | 0.3868 | 0.8628 | — |
MVO2 | |||
n | 33 | 28 | 31 |
LS mean (95% CI), % | 1.5 (–2.2 to 5.2) | 3.0 (–0.8 to 6.7) | 3.0 (–0.4 to 6.4) |
P value vs 20 mg TID | 0.4918 | 0.9791 | — |