Early detection of COPD patients in GOLD 0 population: an observational non-interventional cohort study - MARKO study

Table 2 List of subjects’ assessment through different stages of MARKO study

Assessment	Time/place
	0	2-4	6	12	18	24	60
		w	m	m	m	m	m
	GP	P	GP	GP	GP	P	P
Prescreening	X
Informed consent	X
Inclusion/exclusion criteria	X
MARKO questionnaire	X	X				X	X
CAT		X				X	X
SGRQ		X				X	X
History		X				X	X
Physical		X				X	X
EBT before and after cigarette		X
Lung function
COPD-6™	X	X	X	X	X
Spirometry with bronchodilator test		X				X	X
Impulse oscilometry^a		X
Lung diffusion capacity		X
Body plethysmography^a		X
Blood sampling (hematology; highly sensitive C-reactive protein; blood
stored for DNA, RNA, plasma and serum)^b		X
Functional exercise capacity (6-minute walk test)		X
COPD diagnosis		X				X	X

Legend: w - week, m - month, GP - general practitioner’s office, P - pulmonologist at tertiary care hospital, CAT - COPD Assessment Test, SGRQ - St. George Respiratory Questionnaire, EBT - exhaled breath temperature
^aImpulse oscilometry and body plethysmography was done only in one center
^bBlood sampling was done only in subjects that signed additional Informed consent

ISSN: 1471-2466