Table 2 Mean annual exacerbation rate per patient year in the 12 months post-index date by covariate

0.161 (0.159, 0.163)

0.110 (0.109, 0.111)

GINA Step

Step 1

0.139 (0.136, 0.142)

0.066 (0.063, 0.069)

Step 2

0.143 (0.138, 0.147)

0.070 (0.067, 0.073)

Step 3

0.153 (0.148, 0.158)

0.086 (0.084, 0.089)

Step 4

0.186 (0.181, 0.191)

0.126 (0.123, 0.130)

Step 5

0.455 (0.434, 0.478)

0.512 (0.490, 0.536)

Not classifiable/none

0.105 (0.078, 0.142)

0.113 (0.084, 0.150)

Exacerbations during the 12-month pre-index period

0

0.110 (0.109, 0.112)

0.070 (0.069, 0.071)

1

0.308 (0.301, 0.315)

0.273 (0.265, 0.282)

2

0.674 (0.638, 0.712)

0.644 (0.601, 0.690)

3

1.150 (1.036, 1.276)

1.236 (1.080, 1.414)

≥4

2.195 (1.925, 2.504)

2.687 (2.269, 3.183)

Severe uncontrolled asthma^a

Yes

1.016 (0.939, 1.099)

1.088 (1.002, 1.181)

No

0.153 (0.151, 0.155)

0.098 (0.096, 0.100)

Severe uncontrolled eosinophilic asthma^b

Yes

1.158 (0.828, 1.619)

1.389 (1.127, 1.712)

No

0.153 (0.148, 0.159)

0.132 (0.128, 0.136)