Table 3 Adjusted mean levels of FVC by quartile of inflammatory biomarkers and associations per IQR change
From: FEV1 and FVC and systemic inflammation in a spinal cord injury cohort
CRP (mg/L) | |||||||
|---|---|---|---|---|---|---|---|
|  | Q1 (0.07–0.99) | Q2 (1.00–2.41) | Q3 (2.42–6.91) | Q4 (6.92–161.56) | p-for trend | β (95% CI) L FEV1 per 5.91 mg/L CRP | p-value |
N | 77 | 78 | 78 | 78 | 311 | 311 | 311 |
Basica | 4.02 (3.82, 4.23) | 3.68 (3.47, 3.88) | 3.42 (3.21, 3.62) | 3.27 (3.07, 3.48) | <.0001 | −82.09 (−126.69,-37.49) | 0.0004 |
Fully adjusted | 3.84 (3.63, 4.05) | 3.65 (3.46, 3.83) | 3.52 (3.33, 3.71) | 3.39 (3.20, 3.59) | 0.014 | −65.50 (−106.61,-24.60) | 0.0019 |
Parsimonious adjustedb | 3.83 (3.64, 4.02) | 3.63 (3.45, 3.82) | 3.53 (3.34, 3.71) | 3.40 (3.22, 3.59) | 0.007 | −60.22 (−99.61,-20.84) | 0.003 |
IL-6 (pg/mL) | |||||||
|  | Q1 (0.30–1.26) | Q2 (1.27–2.12) | Q3 (2.13–4.44) | Q4 (4.45–46.8) | p-for trend | β (95% CI) mL FEV1 per 3.18 pg/mL IL-6 |  |
N | 77 | 83 | 76 | 75 | 311 | 311 | 311 |
Basica | 3.85 (3.63, 4.06) | 3.69 (3.49, 3.89) | 3.55 (3.33, 3.76) | 3.29 (3.08, 3.50) | 0.0004 | −125.13 (−194.85,-55.40) | 0.0005 |
Fully adjusted | 3.73 (3.53, 3.93) | 3.62 (3.44, 3.80) | 3.61 (3.42, 3.81) | 3.43 (3.23, 3.63) | 0.0481 | −77.69 (−143.93,-11.46) | 0.0222 |
Parsimonious adjustedb | 3.73 (3.54, 3.92) | 3.62 (3.44, 3.80) | 3.62 (3.43, 3.81) | 3.42 (3.23, 3.61) | 0.0307 | −76.87 (−139.55,-14.19) | 0.0169 |