Table 4 Adjusted mean levels of FEV1/FVC(%) by quartile of inflammatory biomarkers and associations per IQR change
From: FEV1 and FVC and systemic inflammation in a spinal cord injury cohort
CRP (mg/L) | |||||||
|---|---|---|---|---|---|---|---|
|  | Q1 (0.07–0.99) | Q2 (1.00–2.41) | Q3 (2.42–6.91) | Q4 (6.92–161.56) | p-for trend | β (95% CI) FEV1/FVC per 5.91 mg/L CRP | p-value |
N | 77 | 78 | 78 | 78 | 311 | 311 | 311 |
Basica | 76.0 (73.8, 78.2) | 77.2 (75.0, 79.4) | 76.2 (74.0, 78.4) | 78.4 (76.2, 80.6) | 0.14 | −0.068 (−0.536,0.40) | 0.78 |
Fully adjusted | 76.4 (74.1, 78.7) | 77.3 (75.2, 79.3) | 76.3 (74.3, 78.4) | 77.8 (75.6, 79.9) | 0.43 | −0.19 (−0.643,0.262) | 0.41 |
Parsimonious adjustedb | 76.8 (74.7, 79.0) | 77.3 (75.3, 79.4) | 76.0 (74.0, 78.1) | 77.6 (75.5, 79.6) | 0.59 | −0.216 (−0.65,0.217) | 0.33 |
IL-6 (pg/mL) | |||||||
|  | Q1 (0.30–1.26) | Q2 (1.27–2.12) | Q3 (2.13–4.44) | Q4 (4.45–46.8) | p-for trend | β (95% CI) FEV1/FVC per 3.18 pg/mL IL-6 |  |
N | 77 | 83 | 76 | 75 | 311 | 311 | 311 |
Basica | 77.6 (75.3, 79.8) | 76.9 (74.7, 79.0) | 77.1 (74.9, 79.4) | 76.2 (74.0, 78.5) | 0.47 | −0.13 (−0.859,0.599) | 0.73 |
Fully adjusted | 77.5 (75.3, 79.7) | 76.6 (74.6, 78.6) | 77.5 (75.4, 79.6) | 76.2 (74.0, 78.4) | 0.50 | 0.069 (−0.654,0.791) | 0.85 |
Parsimonious adjustedb | 77.9 (75.8, 79.9) | 76.5 (74.5, 78.4) | 77.4 (75.3, 79.5) | 76.1 (74.0, 78.2) | 0.38 | −0.041 (−0.726,0.645) | 0.91 |