Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males

Table 2 Inflammation parameters in blood 6 h after bronchial segmental challenge with placebo, 10 μg, 50 μg, or 100 μg carbon nanoparticles

Peripheral Blood Cells × 10⁹/L	Placebo (n = 9)	10 μg NP (n = 4)	50 μg NP (n = 4)	100 μg NP (n = 9)	P-value
Leukocytes	6.61 ± 0.38	6.10 ± 0.45	7.65 ± 1.13	8.24 ± 0.77	0.061
Neutrophils	4.22 ± 0.38	3.87 ± 0.68	5.24 ± 1.12	5.66 ± 0.69	0.046
Lymphocytes	1.76 ± 0.11	1.64 ± 0.28	1.78 ± 0.17	1.89 ± 0.11	0.934
Monocytes	0.49 ± 0.03	0.48 ± 0.04	0.55 ± 0.08	0.57 ± 0.06	0.156
Eosinophils	0.13 ± 0.03	0.07 ± 0.03	0.07 ± 0.03	0.10 ± 0.04	0.602
Basophils	0.03 ± 0.01	0.04 ± 0.01	0.03 ± 0.01	0.02 ± 0.00	0.970

Values are expressed as mean ± SEM. The correlations between dose of nanoparticles and changes from baseline of cell numbers were non-parametrically analyzed by Spearman correlation. Abbreviations: NP nanoparticles

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