Table 3 Inflammation parameters in blood and BALF 6 h after bronchial segmental challenge with placebo or 100 μg nanoparticles

 Leukocytes, Cells × 10⁹/L

6.60 (4.8–8.5)

8.70 (5.6–12.4)

0.161

 Neutrophils, Cells × 10⁹/L

4.35 (2.9–6.6)

6.15 (3.4–9.7)

0.050

 Lymphocytes, Cells × 10⁹/L

1.76 (1.4–2.3)

1.77 (1.5–2.5)

0.931

 Monocytes, Cells × 10⁹/L

0.52 (0.3–0.6)

0.59 (0.3–0.9)

0.387

 Eosinophils, Cells × 10⁹/L

0.11 (0.1–0.3)

0.07 (0.0–0.4)

0.931

 Basophils, Cells × 10⁹/L

0.03 (0.0–0.1)

0.02 (0.0–0.1)

0.931

 CRP, mg/L

0.50 (0.3–7.4)

0.40 (0.3–3.5)

1.000

 Leukocytes, Cells × 10⁴/ml

9.47 (6.5–36.5)

11.63 (5.7–18.7)

1.000

 Neutrophils, Cells × 10⁴/ml

0.33 (0.1–2.6)

0.58 (0.1–3.8)

0.637

 Lymphocytes, Cells × 10⁴/ml

0.31 (0.1–0.7)

0.40 (0.1–1.6)

0.153

 Monocytes, Cells × 10⁴/ml

-

-

1.000

 Eosinophils, Cells × 10⁴/ml

0.03 (0.0–0.3)

0.00 (0.0–0.1)

0.637

 Macrophages, Cells × 10⁴/ml

8.72 (6.0–33.1)

9.04 (5.0–16.9)

0.347

 Mast cells, Cells × 10⁴/ml

0.00 (0.0–0.0)

0.00 (0.0–0.0)

--

 Plasma cells, Cells × 10⁴/ml

-

-

--

 ECP, ng/ml

0.65 (0.3–2.3)

0.76 (0.1–1.9)

0.347

 MPO, ng/ml

13.91 (5.1–43.3)

14.28 (6.3–35.7)

1.000

 GRO-α, ng/ml

0.60 (0.3–0.9)

0.49 (0.2–1.5)

1.000

 IL-6, pg/ml

5.39 (1.0–57.0)

25.57 (0.2–124.0)

1.000

 IL-8, ng/ml

0.03 (0.0–0.5)

0.13 (0.0–2.2)

1.000

 IL-17, pg/ml

1.60 (1.6–1.6)

1.60 (1.6–1.6)

--

 CXCL-10, ng/ml

0.66 (0.1–5.6)

1.02 (0.1–5.3)

1.000

 MCP-1, ng/ml

0.02 (0.0–0.1)

0.02 (0.0–0.8)

1.000

 MIP-1α, pg/ml

0.15 (0.2–8.5)

3.76 (0.2–31.1)

1.000

 MIP-1β, ng/ml

0.06 (0.0–1.0)

0.48 (0.0–7.1)

1.000

 TNF-α, pg/ml

0.60 (0.6–1.5)

1.15 (0.6–15.1)

0.576

 VEGF, ng/ml

0.78 (0.0–1.7)

0.51 (0.2–1.7)

0.057