The effect of sedation and/or analgesia as rescue treatment during noninvasive positive pressure ventilation in the patients with Interface intolerance after Extubation

Table 1 Baseline characteristics of patients according to sedonalgesia status during NIPPV

	Sedation and/or analgesia (N = 41)	Non sedoanalgesia (N = 39)	P
Age^c, years	68(54 ~ 78)	78(62 ~ 83)	0.077
Male^b	30 (73%)	25 (64%)	0.471
APACHE II at ICU admission^a, points	17.95 ± 6.87	19.28 ± 6.49	0.376
APACHEII at extubation^a, points	10.61 ± 3.89	10.97 ± 5.29	0.725
NIPPV before mechanical ventilation^b	11 (27%)	11(28%)	0.890
Diagnosis
Pneumonia^b	24(59%)	25(64%)	0.610
AECOPD^b	13(32%)	12(31%)	0.928
Other^b	4(10%)	2(5%)	0.676
Interface			0.476
Oral-nasal mask^b	38(93%)	34(87%)
Nasal mask^b	3(7%)	5(13%)
Before extubation
OI^a	230.43 ± 62.33	260.59 ± 77.83	0.059
pH^a	7.44 ± 0.03	7.44 ± 0.04	0.891
PaCO₂ ^a, mmHg	50.46 ± 10.26	47.27 ± 11.43	0.193
body temperature^a	36.73 ± 0.38	36.91 ± 0.53	0.090
RR^a, bpm	20.61 ± 4.69	22.59 ± 6.24	0.112
HR^a, bpm	105.59 ± 15.78	101.36 ± 17.72	0.263
SBP^a, mmHg	140.34 ± 22.69	136.92 ± 18.93	0.463
DBP^a, mmHg	74.51 ± 13.16	73.41 ± 10.53	0.680
Half an hour after extubation
OI^a	266.94 ± 325.79	225.47 ± 67.65	0.438
pH^a	7.44 ± 0.05	7.43 ± 0.04	0.293
PaCO₂ ^a, mmHg	50.34 ± 11.97	50.71 ± 13.53	0.897
RASS at start of NIPPV
-2 to −1 points^b	15(37%)	3(8%)	0.003
0 to 2 points^b	26(73%)	36(72%)
IPAPmax^a, cmH₂O	13.00 ± 2.58	12.74 ± 2.28	0.639
EPAPmax^a, cmH₂O	5.56 ± 0.95	5.44 ± 1.17	0.599

AECOPD acute exacerbation of chronic obstructive pulmonary disease, APACHE II The Acute Physiologic and Chronic Health Evaluation, DBP diastolic blood pressure, EPAP expiratory positive airway pressure, HR heart rate, IPAP inspiratory positive airway pressure, IQR interquartile range, OI oxygenation index, RASS Richmond Agitation Sedation Scale, RR respiratory rate, SBP systolic blood pressure, SD standard deviation
^aResults are expressed as mean ± SD
^bResults are expressed as n(%)
^cResults are expressed as median (IQR)

ISSN: 1471-2466