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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers

Fig. 1

UIP/IPF patient subgroups stratified by disease severity by FEV1, FVC and DLCO have different gene expression profiles. Patient subgroups were identified using hierarchical clustering with Euclidean distance metric and Ward’s linkage (panels a, b, and c). Average DLCO (a), FEV1 (b), and FVC (c) in six UIP/IPF patient subgroups. Panel d shows heat map representation of 2968 DEG (rows) in 143 control and UIP/IPF patients (columns). Genes and patients were ordered using hierarchical clustering. Color bar represents patents subgroups (1st row in heat map), DLCO (2nd row), FEV1 (3rd row), FVC (4th row) and smoking status (5th row). Data are expressed as the mean ± SD. Differential expression analysis was performed using Limma. Comparison of lung function measures was carried out using two-tailed Student’s T-test

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