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Table 3 Laboratory findings of patients before PMX-DHP in anti-MDA-5 Ab positive and negative groups

From: Clinical effects of direct hemoperfusion using a polymyxin B-immobilized fiber column in clinically amyopathic dermatomyositis-associated rapidly progressive interstitial pneumonias

 

Positive (n = 10)

Negative (n = 4)

p value

P/F ratio

140.3 (48.6–242.7)

251 (167–262.5)

0.024*

APACHE II

13 (11–17)

11 (9–15)

0.175

HRCT score, %

233.9 (177.0–309.6)

238.7 (191.8–361.2)

0.777

WBC, /μL

10,300 (3300–15,600)

13,200 (11100–19,400)

0.065

Neut, /μL

9527 (2670–13,603)

12,032 (7825–17,188)

0.258

Lym, /μL

510 (0–1310)

1774 (214–2775)

0.120

Plt (× 104), μL

22.6 (9.4–31.6)

32.5 (29.7–40.7)

0.007*

LDH, U/L

466 (343–1104)

323 (171–462)

0.024*

CRP, mg/dL

0.64 (0.13–4.52)

2.17 (0.14–13)

0.888

KL-6, U/mL

1849 (403–4730)

1168 (390–2725)

0.258

SP-D, ng/mL

71.3 (15–341)

166.1 (116.6–339.9)

0.090

Ferritin, ng/mL

1260.3(13–4362)

215.9 (145.3–701.3)

0.192

HMGB-1, ng/mL

14.6 (2.7–37.4)

8.4 (3.6–30)

0.374

  1. Dates are expressed as group median values. The p values refer to comparisons between the survivors and non-survivors groups. *: p value <0.05
  2. P/F, arterial partial pressure of oxygen/ fraction of inspired oxygen; WBC, white blood cells; Neut, neutrophils; Lym, lymphocytes; Plt, platelets; LDH, lactate dehydrogenase; CK, creatine kinase; CRP, C-reactive protein; KL-6, Krebs von den Lungen-6; SP-D, Surfactant protein-D; HMGB-1, High-mobility group box protein 1; PMX-DHP, direct hemoperfusion therapy using a polymyxin B-immobilized fiber column; anti-MDA-5 Ab, anti-melanoma differentiation-associated gene 5 antibody