Table 3 Cut-off values and the identifying ability of KL-6, SP-D and MMP-2 by ROC curve analysis
Identifying asbestosis | Identifying asbestosis and silicosis | |||||
|---|---|---|---|---|---|---|
KL-6 | SP-D | MMP-2 | KL-6 | SP-D | MMP-2 | |
AUC | 0.874 | 0.757 | 0.641 | 0.751 | 0.657 | 0.655 |
95% CI | 0.815-0.919 | 0.686-0.818 | 0.564-0.712 | 0.679-0.813 | 0.581-0.728 | 0.579-0.725 |
Cut-off value | 216 U/ml | 8.82 ng/ml | 110.6 ng/ml | 222 U/ml | 9.9 ng/ml | 110.6 ng/ml |
Sensitivity, % | 88.4 | 65.1 | 44.2 | 62.5 | 46.6 | 37.5 |
Specificity, % | 73.1 | 76.9 | 86.2 | 81.2 | 88.2 | 95.3 |
Likelihood ratio | 3.28 | 2.82 | 3.19 | 3.32 | 3.96 | 7.97 |