Fig. 5
From: Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis
Antioxidative properties of siRNA-TERRA facilitated the protection against oxidative stress. a Mitochondria and autophagy were observed in A549 cells treated with 120 μM of H2O2 alone for 12 h using TEM. Mitochondria are marked by M. Autophagy is marked by an arrow. Endoplasmic reticulum is marked by ER. b ROS generation was determined using 5 μM of CMH2DCFDA after treatment. siRNA-TERRA significantly decreased ROS generation in A549 cells. c siRNA-TERRA significantly increased superoxide dismutase activities. d siRNA-TERRA significantly increased catalase activities. Each bar represents mean ± SD, n = 6. ** P < 0.01 compared with the normal control group. ## P < 0.01 compared with the H2O2+ siRNA-TERRA negative control group