Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

BMC Pulmonary Medicine

Table 2 Comparison of minor allele and haplotype frequencies in ILVBL gene with the risk of AERD

Locus	Allele	Location	MAF		OR [95% CI]	P^*	P_corr ^**
Locus	Allele	Location	AERD	ATA	OR [95% CI]	P^*	P_corr ^**
rs2074267	C > A	5’-UTR	0.358	0.414	0.79 [0.61–1.03]	0.076	0.699
rs4141356	G > A	5’-UTR	0.447	0.378	1.33 [1.03–1.71]	0.027	0.250
rs718100	T > G	intron 2	0.429	0.344	1.44 [1.11–1.85]	0.005	0.046
rs2074265	C > A	Exon 6 (L213 L)	0.433	0.348	1.43 [1.11–1.84]	0.005	0.049
rs2240299	T > C	intron 9	0.241	0.352	0.58 [0.44–0.78]	2.28 × 10⁻⁴	0.002
rs7507755	G > A	intron 10	0.241	0.352	0.59 [0.44–0.78]	2.38 × 10⁻⁴	0.002
rs1468198	C > T	intron 10	0.475	0.603	0.60 [0.46–0.77]	6.11 × 10⁻⁵	0.001
rs2074261	C > A	intron 14	0.379	0.501	0.61 [0.47–0.79]	1.41 × 10⁻⁴	0.001
rs13301	T > C	3′-flanking	0.387	0.502	0.63 [0.48–0.81]	2.82 × 10⁻⁴	0.003
BL1ht1	CAGA	–	0.316	0.371	0.78 [0.60–1.02]	0.072	0.580
BL1ht3	AAGA	–	0.220	0.242	0.88 [0.65–1.19]	0.410	1.000
BL1ht4	CGGA	–	0.032	0.037	0.86 [0.43–1.75]	0.684	1.000
BL2ht3	CATCT	–	0.135	0.146	0.91 [0.63–1.31]	0.608	1.000
BL2ht4	CATAC	–	0.021	0.028	0.75 [0.32–1.76]	0.508	1.000

MAF minor allele frequency, ATA aspirin tolerant asthmatics, AERD aspirin-exacerbated respiratory disease, OR odd ratio, CI confidence interval
^* P values were obtained using logistic regression analysis controlling age of onset, smoking status and BMI as covariates
^**Corrected P values for multiple comparison using SNPSpD

ISSN: 1471-2466