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Table 2 Comparison of minor allele and haplotype frequencies in ILVBL gene with the risk of AERD

From: Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

Locus

Allele

Location

MAF

OR [95% CI]

P*

Pcorr **

AERD

ATA

rs2074267

C > A

5’-UTR

0.358

0.414

0.79 [0.61–1.03]

0.076

0.699

rs4141356

G > A

5’-UTR

0.447

0.378

1.33 [1.03–1.71]

0.027

0.250

rs718100

T > G

intron 2

0.429

0.344

1.44 [1.11–1.85]

0.005

0.046

rs2074265

C > A

Exon 6 (L213 L)

0.433

0.348

1.43 [1.11–1.84]

0.005

0.049

rs2240299

T > C

intron 9

0.241

0.352

0.58 [0.44–0.78]

2.28 × 10−4

0.002

rs7507755

G > A

intron 10

0.241

0.352

0.59 [0.44–0.78]

2.38 × 10−4

0.002

rs1468198

C > T

intron 10

0.475

0.603

0.60 [0.46–0.77]

6.11 × 10−5

0.001

rs2074261

C > A

intron 14

0.379

0.501

0.61 [0.47–0.79]

1.41 × 10−4

0.001

rs13301

T > C

3′-flanking

0.387

0.502

0.63 [0.48–0.81]

2.82 × 10−4

0.003

BL1ht1

CAGA

0.316

0.371

0.78 [0.60–1.02]

0.072

0.580

BL1ht3

AAGA

0.220

0.242

0.88 [0.65–1.19]

0.410

1.000

BL1ht4

CGGA

0.032

0.037

0.86 [0.43–1.75]

0.684

1.000

BL2ht3

CATCT

0.135

0.146

0.91 [0.63–1.31]

0.608

1.000

BL2ht4

CATAC

0.021

0.028

0.75 [0.32–1.76]

0.508

1.000

  1. MAF minor allele frequency, ATA aspirin tolerant asthmatics, AERD aspirin-exacerbated respiratory disease, OR odd ratio, CI confidence interval
  2. * P values were obtained using logistic regression analysis controlling age of onset, smoking status and BMI as covariates
  3. **Corrected P values for multiple comparison using SNPSpD