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Table 2 Comparison of minor allele and haplotype frequencies in ILVBL gene with the risk of AERD

From: Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

Locus Allele Location MAF OR [95% CI] P* Pcorr **
AERD ATA
rs2074267 C > A 5’-UTR 0.358 0.414 0.79 [0.61–1.03] 0.076 0.699
rs4141356 G > A 5’-UTR 0.447 0.378 1.33 [1.03–1.71] 0.027 0.250
rs718100 T > G intron 2 0.429 0.344 1.44 [1.11–1.85] 0.005 0.046
rs2074265 C > A Exon 6 (L213 L) 0.433 0.348 1.43 [1.11–1.84] 0.005 0.049
rs2240299 T > C intron 9 0.241 0.352 0.58 [0.44–0.78] 2.28 × 10−4 0.002
rs7507755 G > A intron 10 0.241 0.352 0.59 [0.44–0.78] 2.38 × 10−4 0.002
rs1468198 C > T intron 10 0.475 0.603 0.60 [0.46–0.77] 6.11 × 10−5 0.001
rs2074261 C > A intron 14 0.379 0.501 0.61 [0.47–0.79] 1.41 × 10−4 0.001
rs13301 T > C 3′-flanking 0.387 0.502 0.63 [0.48–0.81] 2.82 × 10−4 0.003
BL1ht1 CAGA 0.316 0.371 0.78 [0.60–1.02] 0.072 0.580
BL1ht3 AAGA 0.220 0.242 0.88 [0.65–1.19] 0.410 1.000
BL1ht4 CGGA 0.032 0.037 0.86 [0.43–1.75] 0.684 1.000
BL2ht3 CATCT 0.135 0.146 0.91 [0.63–1.31] 0.608 1.000
BL2ht4 CATAC 0.021 0.028 0.75 [0.32–1.76] 0.508 1.000
  1. MAF minor allele frequency, ATA aspirin tolerant asthmatics, AERD aspirin-exacerbated respiratory disease, OR odd ratio, CI confidence interval
  2. * P values were obtained using logistic regression analysis controlling age of onset, smoking status and BMI as covariates
  3. **Corrected P values for multiple comparison using SNPSpD