Skip to main content

Table 4 Genotype and haplotype association analysis in ILVBL gene with % decline of FEV1 after oral aspirin challenge test in asthmatics

From: Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

Locus Genotype Codominant Dominant Recessive
RR CR CC P* Pcorr ** P* Pcorr ** P* Pcorr **
rs2074267 6.95 ± 0.76 (173) 6.29 ± 0.46 (578) 7.18 ± 0.59 (385) 0.413 1.000 0.207 1.000 0.907 1.000
rs4141356 7.53 ± 0.90 (171) 6.57 ± 0.48 (537) 6.51 ± 0.51 (428) 0.271 1.000 0.484 1.000 0.238 1.000
rs718100 8.27 ± 1.04 (146) 6.36 ± 0.49 (513) 6.56 ± 0.48 (477) 0.138 1.000 0.500 1.000 0.043 0.391
rs2074265 8.15 ± 1.02 (149) 6.46 ± 0.49 (516) 6.48 ± 0.48 (471) 0.120 1.000 0.389 1.000 0.058 0.535
rs2240299 4.99 ± 0.61 (138) 6.33 ± 0.49 (492) 7.51 ± 0.53 (505) 0.006 0.053 0.015 0.139 0.041 0.376
rs7507755 4.99 ± 0.61 (138) 6.33 ± 0.49 (492) 7.50 ± 0.53 (506) 0.006 0.055 0.016 0.145 0.041 0.379
rs1468198 5.67 ± 0.54 (301) 6.59 ± 0.47 (551) 8.02 ± 0.76 (281) 0.004 0.033 0.008 0.072 0.033 0.307
rs2074261 5.76 ± 0.57 (285) 6.47 ± 0.46 (532) 7.88 ± 0.71 (318) 0.006 0.057 0.009 0.078 0.061 0.560
rs13301 5.78 ± 0.57 (287) 6.62 ± 0.47 (533) 7.63 ± 0.69 (315) 0.015 0.139 0.032 0.291 0.064 0.590
  Haplotype  
+/+ −/+ −/−
BL1ht1 7.25 ± 0.55 (444) 6.22 ± 0.46 (555) 6.78 ± 0.82 (135) 0.276 1.000 0.151 1.000 0.949 1.000
BL1ht3 6.89 ± 0.44 (657) 6.22 ± 0.52 (411) 7.58 ± 1.51 (66) 0.693 1.000 0.563 1.000 0.845 1.000
BL1ht4 6.66 ± 0.34 (1053) 7.16 ± 1.24 (80) 3.00 (1) 0.964 1.000 0.943 1.000 0.827 1.000
BL2ht3 6.70 ± 0.38 (829) 6.65 ± 0.67 (285) 6.91 ± 1.77 (22) 0.818 1.000 0.752 1.000 0.845 1.000
BL2ht4 6.72 ± 0.34 (1075) 6.21 ± 1.39 (60) 0.00 (1) 0.564 1.000 0.612 1.000 0.524 1.000
  1. R rare allele, C common allele
  2. *P values were obtained using linear regression analysis controlling age of onset, smoking status and BMI as covariates
  3. **Corrected P values for multiple comparison using SNPSpD