Table 4 Genotype and haplotype association analysis in ILVBL gene with % decline of FEV1 after oral aspirin challenge test in asthmatics
Locus | Genotype | Codominant | Dominant | Recessive | |||||
|---|---|---|---|---|---|---|---|---|---|
RR | CR | CC | P* | Pcorr ** | P* | Pcorr ** | P* | Pcorr ** | |
rs2074267 | 6.95 ± 0.76 (173) | 6.29 ± 0.46 (578) | 7.18 ± 0.59 (385) | 0.413 | 1.000 | 0.207 | 1.000 | 0.907 | 1.000 |
rs4141356 | 7.53 ± 0.90 (171) | 6.57 ± 0.48 (537) | 6.51 ± 0.51 (428) | 0.271 | 1.000 | 0.484 | 1.000 | 0.238 | 1.000 |
rs718100 | 8.27 ± 1.04 (146) | 6.36 ± 0.49 (513) | 6.56 ± 0.48 (477) | 0.138 | 1.000 | 0.500 | 1.000 | 0.043 | 0.391 |
rs2074265 | 8.15 ± 1.02 (149) | 6.46 ± 0.49 (516) | 6.48 ± 0.48 (471) | 0.120 | 1.000 | 0.389 | 1.000 | 0.058 | 0.535 |
rs2240299 | 4.99 ± 0.61 (138) | 6.33 ± 0.49 (492) | 7.51 ± 0.53 (505) | 0.006 | 0.053 | 0.015 | 0.139 | 0.041 | 0.376 |
rs7507755 | 4.99 ± 0.61 (138) | 6.33 ± 0.49 (492) | 7.50 ± 0.53 (506) | 0.006 | 0.055 | 0.016 | 0.145 | 0.041 | 0.379 |
rs1468198 | 5.67 ± 0.54 (301) | 6.59 ± 0.47 (551) | 8.02 ± 0.76 (281) | 0.004 | 0.033 | 0.008 | 0.072 | 0.033 | 0.307 |
rs2074261 | 5.76 ± 0.57 (285) | 6.47 ± 0.46 (532) | 7.88 ± 0.71 (318) | 0.006 | 0.057 | 0.009 | 0.078 | 0.061 | 0.560 |
rs13301 | 5.78 ± 0.57 (287) | 6.62 ± 0.47 (533) | 7.63 ± 0.69 (315) | 0.015 | 0.139 | 0.032 | 0.291 | 0.064 | 0.590 |
| Â | Haplotype | Â | |||||||
+/+ | −/+ | −/− | |||||||
BL1ht1 | 7.25 ± 0.55 (444) | 6.22 ± 0.46 (555) | 6.78 ± 0.82 (135) | 0.276 | 1.000 | 0.151 | 1.000 | 0.949 | 1.000 |
BL1ht3 | 6.89 ± 0.44 (657) | 6.22 ± 0.52 (411) | 7.58 ± 1.51 (66) | 0.693 | 1.000 | 0.563 | 1.000 | 0.845 | 1.000 |
BL1ht4 | 6.66 ± 0.34 (1053) | 7.16 ± 1.24 (80) | 3.00 (1) | 0.964 | 1.000 | 0.943 | 1.000 | 0.827 | 1.000 |
BL2ht3 | 6.70 ± 0.38 (829) | 6.65 ± 0.67 (285) | 6.91 ± 1.77 (22) | 0.818 | 1.000 | 0.752 | 1.000 | 0.845 | 1.000 |
BL2ht4 | 6.72 ± 0.34 (1075) | 6.21 ± 1.39 (60) | 0.00 (1) | 0.564 | 1.000 | 0.612 | 1.000 | 0.524 | 1.000 |