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Table 4 Associations of asthma status determined by NLP and manual chart review with known risk factors for asthma (construct validity)

From: Automated chart review utilizing natural language processing algorithm for asthma predictive index

  By NLP By manual chart review
No asthma (n = 392) Asthma (n = 35) ORd
(95% CI)
p-value No asthma (n = 391) Asthma (n = 36) ORd
(95% CI)
p-value
Age,a years, median (IQR) 5.2
(3.4, 6.7)
6.2
(4.6, 6.8)
1.2
(1.0, 1.4)
.01 5.1
(3.5, 6.7)
6.3
(4.4, 6.8)
1.2
(1.0, 1.4)
.02
Male, n (%) 188 (47%) 21
(60%)
1.6
(0.8, 3.2)
.17 188 (48%) 21
(58%)
1.5
(0.7, 3.0)
.23
White, n (%) 290 (75%) 25
(71%)
0.8
(0.3, 1.7)
.62 288 (75%) 27
(75%)
1.0
(0.4, 2.2)
.97
Birth weight, median (IQR) 3.14 (2.5,3.5) 2.8 (2.3,3.4) 0.9
(0.9, 1.0)
.08 3.1
(2.5–3.5)
2.8
(2.4–3.4)
0.9
(0.9, 1.0)
.14
Cesarean section, n(%) 115 (29%) 11
(31%)
1.1 (0.5,2.3) .79 116 (30%) 10
(28%)
0.9
(0.4–1.9)
.81
Gestational age, median (IQR) 37 (36,39) 36 (36,37) 0.8
(0.6, 1.0)
.07 37 (36,39) 36 (36,38) 0.8
(0.7, 1.0)
.15
Allergic rhinitis, n (%) 31
(8%)
8
(23%)
3.4
(1.4, 8.2)
< .01 31
(8%)
8
(22%)
3.3
(1.3, 7.8)
< .01
Eczema, n (%) 87
(22%)
15
(44%)
2.7
(1.3, 5.6)
< .01 86
(22%)
16
(44%)
2.8
(1.3, 5.6)
< .01
Family history of asthma, n (%) 80
(20%)
21
(60%)
5.8
(2.8, 12.0)
< .01 80
(20%)
21
(58%)
5.4 (2.6,11.0) < .01
Family history of atopic diseases, n(%) 150 (38%) 14
(40%)
1.0
(0.5–2.1)
.83 148 (37%) 16
(44%)
1.3
(0.6–2.6)
.43
Passive smoke exposure, n (%) 51 (14%) 8 (24%) 1.9
(0.8–4.5)
.11 51
(14%)
8
(24%)
1.8
(0.8–4.3)
.13
Maternal smoking,bn (%) 25
(6%)
8
(23%)
4.4
(1.8, 10.7)
< .01 25
(7%)
8
(23%)
4.2 (1.7,10.3) < .01
Childcare attendance,cn (%) 165 (42%) 18
(51%)
1.4
(0.7, 2.9)
.28 164 (42%) 19
(53%)
1.5
(0.7, 3.0)
.21
Breastfeeding, n (%) 327 (85%) 27
(82%)
0.8
(0.3, 2.0)
.66 325 (84%) 29
(85%)
1.0
(0.3, 2.8)
.89
  1. aAge at the last follow-up date
  2. bmaternal smoking status during pregnancy
  3. cChildcare attendance before 3 years
  4. dUnadjusted Odds ratio