Table 4 Associations of asthma status determined by NLP and manual chart review with known risk factors for asthma (construct validity)
From: Automated chart review utilizing natural language processing algorithm for asthma predictive index
| Â | By NLP | By manual chart review | ||||||
|---|---|---|---|---|---|---|---|---|
No asthma (n = 392) | Asthma (n = 35) | ORd (95% CI) | p-value | No asthma (n = 391) | Asthma (n = 36) | ORd (95% CI) | p-value | |
Age,a years, median (IQR) | 5.2 (3.4, 6.7) | 6.2 (4.6, 6.8) | 1.2 (1.0, 1.4) | .01 | 5.1 (3.5, 6.7) | 6.3 (4.4, 6.8) | 1.2 (1.0, 1.4) | .02 |
Male, n (%) | 188 (47%) | 21 (60%) | 1.6 (0.8, 3.2) | .17 | 188 (48%) | 21 (58%) | 1.5 (0.7, 3.0) | .23 |
White, n (%) | 290 (75%) | 25 (71%) | 0.8 (0.3, 1.7) | .62 | 288 (75%) | 27 (75%) | 1.0 (0.4, 2.2) | .97 |
Birth weight, median (IQR) | 3.14 (2.5,3.5) | 2.8 (2.3,3.4) | 0.9 (0.9, 1.0) | .08 | 3.1 (2.5–3.5) | 2.8 (2.4–3.4) | 0.9 (0.9, 1.0) | .14 |
Cesarean section, n(%) | 115 (29%) | 11 (31%) | 1.1 (0.5,2.3) | .79 | 116 (30%) | 10 (28%) | 0.9 (0.4–1.9) | .81 |
Gestational age, median (IQR) | 37 (36,39) | 36 (36,37) | 0.8 (0.6, 1.0) | .07 | 37 (36,39) | 36 (36,38) | 0.8 (0.7, 1.0) | .15 |
Allergic rhinitis, n (%) | 31 (8%) | 8 (23%) | 3.4 (1.4, 8.2) | < .01 | 31 (8%) | 8 (22%) | 3.3 (1.3, 7.8) | < .01 |
Eczema, n (%) | 87 (22%) | 15 (44%) | 2.7 (1.3, 5.6) | < .01 | 86 (22%) | 16 (44%) | 2.8 (1.3, 5.6) | < .01 |
Family history of asthma, n (%) | 80 (20%) | 21 (60%) | 5.8 (2.8, 12.0) | < .01 | 80 (20%) | 21 (58%) | 5.4 (2.6,11.0) | < .01 |
Family history of atopic diseases, n(%) | 150 (38%) | 14 (40%) | 1.0 (0.5–2.1) | .83 | 148 (37%) | 16 (44%) | 1.3 (0.6–2.6) | .43 |
Passive smoke exposure, n (%) | 51 (14%) | 8 (24%) | 1.9 (0.8–4.5) | .11 | 51 (14%) | 8 (24%) | 1.8 (0.8–4.3) | .13 |
Maternal smoking,bn (%) | 25 (6%) | 8 (23%) | 4.4 (1.8, 10.7) | < .01 | 25 (7%) | 8 (23%) | 4.2 (1.7,10.3) | < .01 |
Childcare attendance,cn (%) | 165 (42%) | 18 (51%) | 1.4 (0.7, 2.9) | .28 | 164 (42%) | 19 (53%) | 1.5 (0.7, 3.0) | .21 |
Breastfeeding, n (%) | 327 (85%) | 27 (82%) | 0.8 (0.3, 2.0) | .66 | 325 (84%) | 29 (85%) | 1.0 (0.3, 2.8) | .89 |