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Fig. 3 | BMC Pulmonary Medicine

Fig. 3

From: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension

Fig. 3

Eplerenone has no direct effect on pressure overload-induced structural RV remodeling. Pharmacological aldosterone antagonism with Eplerenone had no effect on RV total collagen content assessed by picrosirius red stains (percentage of the total RV; a), Col1A1 (percentage of sham; b) and Col3A1 gene expression (percentage of sham; c). Eplerenone did not affect cardiomyocyte hypertrophy (CM diameter, μm; d), ANP (e) or BNP gene expression (percentage of sham; f). n = 4–5 mice per group; *: p < 0.05 vs. cntrl

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BMC Pulmonary Medicine

ISSN: 1471-2466

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