Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma

BMC Pulmonary Medicine

Table 5 Multi-variable regression analysis of lung function and ACQ6 by sex hormone levels in females 6–18 years with asthma

Outcome variable	Covariate remaining in the model*	Beta coefficient	Covariate p value	R squared	P value of the model
Pre-BD FEV₁ (%)	Estradiol	−0.457	0.028	0.209	0.028
Post-BD FEV₁ (%)	Estradiol	−0.454	0.005	0.320	0.005
Pre-BD FVC (%)	Estradiol	−0.351	0.025	0.217	0.025
Post-BD FVC (%)	Estradiol	−0.322	0.015	0.249	0.015
ACQ6	log (DHEA-S)	0.006	0.048	0.173	0.048

*Results reflect final results of a model that started with log (DHEA-S), estradiol, progesterone, and free testosterone as covariates. Covariates that were not significantly associated with the outcome in this model were then removed by backward selection and model was re-run with remaining variables

ISSN: 1471-2466