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Table 1 Clinical characteristics and day-to-isolation univariate analysis (N = 69)

From: Delayed isolation of smear-positive pulmonary tuberculosis patients in a Japanese acute care hospital

Characteristic

No.(%) or mean ± SD

Day-to-isolation

(95% CI)

p-value

Patient factor

 Age (years)

81.1 ± 10.0

 

0.827

 Male gender-no.(%)

51 (73.9)

8.2 (3.90–12.41)

0.009*

 Female gender-no.(%)

18 (26.1)

1.8 (0.70–2.86)

 

 Smoking-no.(%)

40 (58.0)

6.6 (3.16–10.09)

0.585

 Non-smoking-no.(%)

29 (42.0)

6.3 (0.24–12.38)

 

 Alcoholism-no.(%)

4 (5.8)

1.5 (0.52–2.48)

0.217

 Non-alcoholism-no.(%)

65 (94.2)

6.8 (3.40–10.21)

 

 Welfare recipient-no.(%)

4 (5.8)

1.3 (0.76–1.74)

0.172

 Non-welfare recipient-no.(%)

65 (94.2)

6.8 (3.41–10.22)

 

 Dependent ADL-no.(%)

12 (17.4)

11.5 (2.67–20.33)

0.129

 Partially dependent ADL-no.(%)

20 (29.0)

8.7 (0.08–17.22)

 

 Independent ADL-no.(%)

37 (53.6)

3.7 (1.28–6.13)

 

 Past history of tuberculosis-no.(%)

28 (40.6)

3.0 (1.44–4.49)

0.073

 Non-past history of tuberculosis-no.(%)

41 (59.4)

8.9 (3.69–14.12)

 

 Contact with tuberculosis patients-no.(%)

7 (10.1)

3.3 (0.01–6.56)

0.519

 Non-contact with tuberculosis patients-no.(%)

62 (89.9)

6.9 (3.30–10.41)

 

 Diabetes mellitus-no.(%)

25 (37.3)

3.8 (1.19–6.49)

0.248

 Non-diabetes mellitus-no.(%)

42 (60.9)

8.3 (3.31–13.31)

 

 Other lung disease-no.(%)

18 (26.1)

5.3 (0.73–9.83)

0.864

 Non-other lung disease-no.(%)

51 (73.9)

6.9 (2.86–10.99)

 

 Gastric resection-no.(%)

8 (11.6)

4.8 (0.00–11.02)

0.593

 Non-gastric resection-no.(%)

61 (88.4)

6.7 (3.16–10.28)

 

 Human immunodificiency virus infection -no.(%)

1 (1.4)

1.0 (1.00–1.00)

0.366

 Non-human immunodificiency virus infection-no.(%)

68 (98.6)

6.6 (3.31–9.84)

 

 Preceding newer quinolone antibiotics-no.(%)

6 (8.7)

23.0 (0.00–51.14)

0.027*

 Non-preceding newer quinolone antibiotics-no.(%)

63 (91.3)

4.9 (2.77–7.07)

 

 Steroid use-no.(%)

15 (21.7)

6.5 (0.38–12.55)

0.923

 Non-steriod use-no.(%)

54 (78.3)

6.5 (2.72–10.28)

 

 Chronic cough-no.(%)

19 (27.5)

2.3 (0.81–3.82)

0.023*

 Absence of chronic cough-no.(%)

50 (72.5)

8.1 (3.74–12.42)

 

 Appetite loss-no.(%)

48 (70.6)

8.5 (3.96–13.00)

0.037*

 Absence of appetite loss-no.(%)

20 (29.0)

2.0 (1.36–2.64)

 

 BMI (kg/m2)

19.0 ± 3.3

 

0.213

 BT on arrival (°C)

37.2 ± 1.8

 

0.335

 sBP on arrical (mmHg)

123.5 ± 30.3

 

0.768

 Oxygen requirement-no.(%)

25 (36.2)

8.2 (0.89–15.51)

0.555

 Non-oxygen requirement-no.(%)

44 (63.8)

5.5 (2.60–8.44)

 

 Haemoglobin level (g/dL)

11.9 ± 1.9

 

0.783

 Serum albumin level (g/dL)

2.9 ± 0.6

 

0.348

 CRP level (mg/dL)

9.3 ± 5.6

 

0.748

 Cavitary lesion on the chest radiograph-no.(%)

15 (21.7)

1.3 (1.04–1.50)

0.005*

 Non-cavitary lesion on the chest radiograph-no.(%)

54 (78.3)

7.9 (3.91–11.98)

 

 Upper zone lesion on the chest radiograph-no.(%)

36 (52.2)

3.3 (1.33–5.17)

0.015*

 Lesion located other than in the upper zone on the chest radiograph-no.(%)

33 (47.8)

10.0 (3.80–16.26)

 

 Disseminated lesion on the chest radiograph-no.(%)

32 (46.4)

3.3 (0.72–5.91)

0.028*

 Non-disseminated lesion on the chest radiograph-no.(%)

37 (53.6)

9.2 (3.79–14.70)

 

 Raw score (from −30 points to 60 points)

29.2 ± 18.0

 

0.973

Medical facility and doctor factor

 Year of hospital visit (from 2008 to 2016)

2012.4 ± 2.6

 

0.151

 Night-time arrival-no.(%)

27 (39.1)

8.7 (1.87–15.47)

0.248

 Day-time arrival-no.(%)

42 (60.9)

5.1 (2.11–8.08)

 

 Weekend arrival-no.(%)

13 (18.8)

3.8 (1.06–6.48)

0.517

 Weekday arrival-no.(%)

56 (81.2)

7.1 (3.22–11.03)

 

 Medical care provided by resident-no.(%)

27 (39.1)

7.1 (0.72–13.58)

0.844

 Medical care provided by non-resident-no.(%)

42 (60.9)

6.1 (2.71–9.44)

 

 Medical care provided by male doctor-no.(%)

60 (87.0)

5.9 (2.64–9.20)

0.407

 Medical care provided by female doctor-no.(%)

9 (13.0)

10.3 (0.00–22.07)

 

 Transferred to the hospital by ambulance-no.(%)

39 (56.5)

7.9 (2.74–13.16)

0.523

 Transferred to the hospital by non-ambulance-no.(%)

30 (43.5)

4.6 (1.63–7.57)

 

 Attending ER physician-no.(%)

55 (79.7)

6.3 (2.53–10.05)

0.580

 Attending non-ER physician-no.(%)

14 (20.3)

7.3 (1.27–13.30)

 
  1. Raw score is tuberculosis prognostic score, which is calculated as follows:
  2. age(years) + (oxygen requirement, 10 points) − 20 × albumin (g/dl) + (ADL: independent, 0 point; semi-dependent, 5 points; totally dependent, 10 points)
  3. Resident indicate physician who was graduated within two years
  4. Based on logrank test or cox hazard crude model, where appropriate, *p < 0.05
  5. CI confidence interval, SD = standard deviation, ADL activities of daily living, BMI body mass index, BT body temperature, sBP systolic blood pressure, CRP C-reactive protein, ER emergency room