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Table 2 Changes in sputum properties, pulmonary diffusing capacity and oxygen saturation during experiments A and B (N = 15)

From: Acute effects of combined exercise and oscillatory positive expiratory pressure therapy on sputum properties and lung diffusing capacity in cystic fibrosis: a randomized, controlled, crossover trial

 

Experiment A

Experiment B

Variables

Pre-exercise

Post-exercise

45 min post-exercise

P-value

Pre-exercise

Post-exercise

45 min post-exercise

P-value

Sputum properties

 G’ 1 rad s−1 (Pa)

6.7 (4.2, 9.7)

10.3 (6.0; 20.3)

14.1 (6.1, 19.0)

0.057

7.5 (4.1, 13.0)

8.8 (6.5, 13.8)

13.3 (7.1, 14.6)

0.085

 G’ 10 rad s−1 (Pa)

10.2 (6.4, 14.4)

15.9 (8.3, 28.1)

20.9 (9.7, 26.0)

0.062

11.5 (5.9, 20.1)

13.6 (8.8, 18.0)

20.0 (10.1, 23.0)

0.155

 G” 1 rad s−1 (Pa)

2.3 (1.7, 3.2)

3.1 (2.1, 5.9)

3.8 (2.0, 6.2)

0.085

2.6 (1.3, 3.6)

3.2 (2.3, 4.9)

4.5 (2.5, 4.9)

0.155

 G” 10 rad s−1 (Pa)

2.9 (2.2, 4.0)

3.7 (2.6, 6.6)

4.2 (2.6, 6.7)

0.085

3.6 (1.8, 4.3)

3.7 (2.8, 5.7)

5.3 (2.9, 6.1)

0.282

 Dynamic yield stress (Pa)

0.20 (0.10, 0.30)

0.30 (0.20, 0.60)

0.30 (0.20, 0.40)

0.066

0.20 (0.10, 0.40)

0.20 (0.18, 0.33)

0.30 (0.2, 0.53)

0.074

 Sputum solids content (%)

5.3 (3.9, 7.4)

6.2 (4.2, 9.7)

6.5 (4.4, 8.1)

0.038

4.5 (3.6, 5.8)

6.2 (4.1, 7.5)

6.9 (3.8, 8.4)

0.672

 Spinnability (mm)

6.7 (6.4, 8.2)

7.7 (6.5, 21.0)

6.7 (6.3, 8.2)

0.155

9.2 (6.4, 12.4)

6.2 (5.8, 8.3)

8.9 (7.2, 31.0)

0.089

 Ease of sputum expectoration (cm)

8.1 (5.2, 8.3)

7.7 (3.4, 9.3)

8.2 (4.7, 8.9)

0.180

7.1 (5.2, 8.7)

6.5 (4.4, 9.1)

5.3 (4.3, 9.2)

0.482

Pulmonary diffusing capacity

DLNO (mL min− 1 mmHg− 1)

78.1 (68.4, 141.6)

86.9 (67.4, 140.6)

79.2 (65.6, 134.0)

0.015*

84.7 (64.8, 143.1)

83.8 (69.9, 135.2)

82.6 (69.4, 147.8)

0.482

DLNO/VA (mL min− 1 mmHg− 1 L− 1)

21.1 (19.8; 22.4)

21.2 (20.0; 22.2)

20.7 (18.2; 21.8)

0.015

21.1 (19.7; 22.7)

20.5 (19.2; 22.4)

20.7 (18.3, 22.3)

0.007

DLCO (mL min− 1 mmHg− 1)

22.4 (20.3, 31.9)

24.6 (20.3, 36.2)

21.5 (19.5, 31.1)

0.002*

23.7 (19.6, 34.3)

24.2 (19.4, 34.0)

22.9 (19.3, 32.5)

0.011*

DLCO/VA (mL min− 1 mmHg− 1 L− 1)

5.8 (5.2, 6.1)

6.1 (5.4, 6.5)

5.6 (5.3, 6.2)

0.047*

5.7 (5.4, 6.01)

6.0 (5.3, 6.2)

5.5 (5.0, 5.9)

< 0.001*♯

DLNO/DLCO ratio

3.8 (3.4, 4.1)

3.6 (3.4, 3.8)

3.6 (3.4, 4.1)

0.025

3.8 (3.4, 4.2)

3.5 (3.3, 3.9)

3.7 (3.3, 4.1)

0.005

DMCO (mL min−1 mmHg− 1)

52 (42, 112)

56 (43, 88)

53 (43, 92)

0.612

58 (42, 106)

54 (45, 89)

56 (42, 118)

0.717

 VA (L)

3.8 (3.4, 6.0)

4.2 (3.5, 6.1)

3.9 (3.4, 5.6)

0.001

3.9 (3.3, 5.9)

3.9 (3.5, 5.5)

4.0 (3.6, 6.0)

0.420

 Vcap (mL)

76 (69, 82)

91 (77, 91)

76 (67, 91)

< 0.001*

75 (72, 94)

82 (76, 92)

75 (67, 83)

0.015*

Oxygen saturation

 SpO2 (%)

97.0 (95.8, 97.0)

96.0 (94.8, 97.0)

96.0 (95.5, 97.0)

0.598

96.5 (96.0, 97.6)

96.0 (96.0, 97.3)

97.0 (96.8, 98.0)

0.125

  1. Data are displayed as median (interquartile range, IQR). DLCO, diffusing capacity of the lung for carbon monoxide; DLNO, diffusing capacity of the lung for nitric oxide; DMCO, alveolar-capillary membrane diffusing capacity for carbon monoxide; G’, storage modulus; G”, loss modulus; SpO2, oxygen saturation; VA, alveolar volume; Vcap, pulmonary capillary blood volume. Pulmonary gas diffusion variables were measured in SI units (mmol min− 1 kPa− 1) and converted to traditional units (mL min− 1 mmHg− 1) by multiplying with 2.987. Differences in outcome variables between the three different time points during each experimental condition (experiment A and B) were analyzed using the non-parametric Friedman test followed by a Wilcoxon-signed rank test. The Wilcoxon signed-rank test was only performed, if changes over time were significant (P < 0.05)
  2. *indicates significant differences between pre- and post-exercise values based on Wilcoxon signed-rank test (P < 0.05)
  3. ♯ indicates significant differences between pre- and 45′ post-exercise values based on Wilcoxon signed-rank test (P < 0.05)