Table 1 Clinical characteristics of latent classes in the Royal Brompton cohort
Class | P value | Adjusted P value | |||
|---|---|---|---|---|---|
1 | 2 | 3 | |||
N = 14 | N = 38 | N = 33 | |||
Female Sex | 9 (64.3%) | 22 (57.9%) | 23 (69.7%) | 0.571 | 0.670 |
Age (years) | 72.4 (±10.0) | 61.5 (±11.1) | 66.8 (±9.1) | 0.003 | 0.037 |
Smoking | 0.411 | 0.575 | |||
Never smoker | 6 (42.9%) | 18 (47.4%) | 17 (51.5%) | ||
Ex-smoker | 5 (35.7%) | 16 (42.1%) | 15 (45.5%) | ||
Current smoker | 3 (21.4%) | 4 (10.5%) | 1 (3.0%) | ||
White - British Ethnicity | 12 (85.7%) | 30 (78.9%) | 28 (84.8%) | 0.747 | 0.747 |
Diagnosis | 0.006 | 0.039 | |||
Bronchiectasis | 5 (35.7%) | 13 (34.2%) | 25 (75.8%) | ||
COPD | 5 (35.7%) | 11 (28.9%) | 4 (12.1%) | ||
Other | 0 (0.0%) | 6 (15.8%) | 2 (6.1%) | ||
No underlying disease | 4 (28.6%) | 8 (21.1%) | 2 (6.1%) | ||
Systemic corticosteroids | 4 (28.6%) | 7 (18.4%) | 5 (15.2%) | 0.574 | 0.670 |
Oral antibiotic prophylaxis | 2 (14.3%) | 9 (23.7%) | 11 (33.3%) | 0.404 | 0.575 |
Nebulised antibiotic prophylaxis | 1 (7.1%) | 2 (5.3%) | 4 (12.1%) | 0.677 | 0.702 |
Chronic Pseudomonas infection | 0 (0.0%) | 3 (7.9%) | 7 (21.2%) | 0.088 | 0.176 |
Semi-invasive Aspergillosis | 2 (14.3%) | 1 (2.6%) | 0 | 0.069 | 0.155 |
NTM species | 0.612 | 0.685 | |||
M. abscessus | 4 (28.6%) | 4 (10.5%) | 6 (18.2%) | ||
M. avium complex | 7 (50.0%) | 18 (47.4%) | 19 (57.6%) | ||
M. kansasii | 1 (7.1%) | 4 (10.5%) | 4 (12.1%) | ||
M. xenopi | 1 (7.1%) | 8 (21.1%) | 2 (6.1%) | ||
Other species | 1 (7.1%) | 4 (10.5%) | 2 (6.1%) | ||
Sputum smear positive | 1 (7.1%) | 3 (7.9%) | 5 (15.2%) | 0.639 | 0.688 |
Currently receiving NTM treatment | 6 (42.9%) | 8 (21.1%) | 4 (12.1%) | 0.072 | 0.155 |
Ever received NTM treatment | 11 (78.6%) | 15 (39.5%) | 11 (33.3%) | 0.015 | 0.060 |
Duration of NTM disease (years) | 3.4 (±3.2) | 1.6 (±2.6) | 4.3 (±4.7) | 0.01 | 0.047 |
Age at diagnosis (years) | 69.6 (±9.9) | 60.0 (±11.5) | 62.5 (±10.6) | 0.035 | 0.098 |
BMI (kg/m2) | 18.3 (±3.2) | 22.6 (±4.3) | 22.3 (±3.4) | 0.004 | 0.037 |
SGRQ total score | 51.3 (±24.6) | 42.1 (±26.1) | 48.1 (±21.6) | 0.443 | 0.591 |
MRC dyspnoea score | 2.9 (±1.4) | 2.4 (±1.5) | 2.6 (±1.1) | 0.513 | 0.653 |
FEV1 (% predicted) | 58.7 (±13.3) | 69.5 (±27.6) | 53.9 (±20.1) | 0.024 | 0.081 |
FVC (% predicted) | 83.1 (±27.0) | 97.7 (±20.8) | 85.8 (±16.8) | 0.026 | 0.081 |
TLCOc (% predicted) | 47.9 (±24.1) | 62.2 (±26.0) | 59.2 (±18.2) | 0.25 | 0.389 |
Haemoglobin (g/dL) | 12.7 (±1.7) | 13.7 (±1.6) | 13.7 (±1.1) | 0.049 | 0.125 |
Neutrophil count (× 109/L) | 7.0 (±2.9) | 5.3 (±3.0) | 6.1 (±3.1) | 0.186 | 0.326 |
Lymphocyte count (× 109/L) | 1.4 (±0.5) | 1.6 (±0.6) | 1.8 (±0.7) | 0.242 | 0.389 |
Serum albumin (g/L) | 36.0 (±6.3) | 40.2 (±3.7) | 38.2 (±3.9) | 0.007 | 0.039 |
CRP (mg/L) | 37.2 (±51.1) | 7.1 (±13.7) | 10.0 (±13.5) | < 0.001 | 0.017 |
Platelet count (× 109/L) | 298 (±126) | 244 (±62) | 255 (±86) | 0.126 | 0.235 |