Fig. 1

a. Prior to treatment with crizotinib, a chest CT scan revealed a large irregularly shaped mass on the upper right lobe, accompanied by multiple nodules, plaques and consolidated masses of diverse sizes randomly distributed in both lung fields. Nodular thickening of the interlobular septa and fissures, which suggested lymphangitis carcinomatosa, hilar and mediastinal lymphadenopathy, and bilateral pleural effusions, were identified as well. b Ten days after the initiation of crizotinib, chest CT revealed a significant shrinkage of intrapulmonary neoplastic lesions, lymphadenitis and lymphadenectasis but not of multiple new-onset ground-glass opacities and consolidation lesions throughout both lungs