Fig. 4

Genomic organization of somatic alterations identified in our patient. a complex indel lying in EGFR exon 19, which affects the protein tyrosine kinase domain. b Translocation resulted in a fusion product with exons 1 and 2 of SDC4 and exons 32–43 of ROS1, including the protein tyrosine kinase domain. Abbreviations of protein domains: Recep L, receptor L domain; Furin-like, furin-like cysteine-rich region; GF recep IV, growth factor receptor domain IV; Pkinase Tyr, protein tyrosine kinase domain; fn3, fibronectin type III domain; Syndecan, syndecan domain