Table 5 COPD treatment by number of comorbidities and COPD severity (P value refers to compare each pharmacologic treatment according to number of comorbidities in each severity stage)
From: Comorbidities and COPD severity in a clinic-based cohort
Number of comorbidities | A N = 435 | B N = 391 | C N = 178 | D N = 580 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
0–1 N = 281 | > = 2 N = 154 | p | 0–1 N = 194 | > = 2 N = 197 | p | 0–1 N = 117 | > = 2 N = 61 | p | 0–1 N = 272 | > = 2 N = 308 | p | |
SABA, n(%) | 83(29.5) | 42(27.2) | 0.61 | 81(41.7) | 92(46.7) | 0.32 | 46(39.3) | 20(32.8) | 0.39 | 94(34.5) | 179(58.2) | < 0.0001 |
LABA or LAMA, n(%) | 152(54.0) | 79(51.3) | 0.57 | 139(71.6) | 143(72.6) | 0.83 | 72(61.5) | 47(77.0) | 0.03 | 186(68.4) | 227(73.7) | 0.15 |
ICS and LABA, n(%) | 53(18.9) | 26(16.9) | 0.60 | 55(28.3) | 42(21.3) | 0.10 | 31(26.5) | 12(19.7) | 0.31 | 102(37.5) | 124(40.3) | 0.49 |
LABA and LAMA, n(%) | 30(10.7) | 23(14.9) | 0.02 | 26(13.4) | 38(19.3) | 0.01 | 18(15.4) | 19(31.1) | 0.02 | 45(16.5) | 94(30.5) | 0.01 |
LABA and LAMA and ICS, n(%) | 1(0.35) | 1(0.64) | 0.35 | 2(1.03) | 2(1.01) | 0.35 | 2(1.7) | 2(3.2) | 0.35 | 8(2.9) | 21(6.8) | 0.02 |
Pulmonary Rehabilitation, n(%) | 8(2.8) | 4(2.6) | 0.87 | 6(3.9) | 17(8.6) | 0.02 | 7(6) | 3(5) | 0.76 | 31(11.4) | 66(21.4) | 0.0012 |
Annual influenza vaccination, n(%) | 105(37.4) | 61(39.6) | 0.64 | 95(49) | 135(68.5) | < 0.0001 | 60(51.3) | 33(54.1) | 0.72 | 167(61.4) | 243(79) | < 0.0001 |
Pneumococcal vaccination, n(%) | 85(30.2) | 56(36.3) | 0.19 | 81(41.7) | 123(62.4) | < 0.0001 | 65(55.5) | 35(57.3) | 0.81 | 145(53.3) | 234(76) | < 0.0001 |
Smoking cessation, n(%) | 24(8.5) | 11(7.14) | 0.60 | 13(6.7) | 10(5.0) | 0.49 | 13(11.1) | 13(21.3) | 0.06 | 17(6.2) | 41(13.3) | 0.0047 |