Fig. 1
From: Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease
The aerosol deposition measurement system. The aerosol deposition measurement system can be divided into three sub-systems. Aerosol generation system (blue): the test aerosol is generated by an electrospray aerosol, followed by size-selection and dilution with particle free air. Inhalation system (red): a four-way, high-speed, computer-controlled valve directs particle free air or test aerosol to the subject, monitors the breathing pattern and collects exhaled samples from a well-defined volumetric sample depth. The system is enclosed in a temperature controlled box held at 35°c. Particle detection system (green): the particle number concentration in the test aerosol and in exhaled samples are measured with a condensation particle counter