Fig. 3
From: Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
Shp2 inhibition ameliorates muscularization of pulmonary arterioles in MCT induced PAH rats. a Phps-1 decreased α-SMA expression of lungs in MCT induced PAH. Representative images of immunofluorescent stainings for CD31 (red) and α-SMA (green) in lungs were showed. Nucleus (blue) was stained with DAPI. Scale bar = 50 μm. b The muscularization of distal pulmonary arterioles was determined by calculating the percent of arteries that were fully (> 75%), partially (25–75%) and not muscularuized (< 25%) (n = 4–6). Data was presented as means ± standard deviation (SD), *** P < 0.001