Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study

BMC Pulmonary Medicine

Table 4 Clinical characteristics of patients with and without acute exacerbation after the second surgery

Variable^a	With AE (n = 3)	Without AE (n = 10)	p Value^b
Sex
Male	3	8	0.577
Female	0	2	0.577
Type of multiple cancer
Synchronous	1	5	0.563
Metachronous	2	5	0.563
Smoking history
PY < 30	0	2	0.577
PY ≥30	3	8	0.577
FEV1%, mean	87.5 ± 11.2	83.3 ± 6.6	0.455
%VC, mean	64.4 ± 19.7	80.9 ± 19.0	0.234
Rate of %VC decrease from initial surgery, mean	35.9 ± 11.7	20.1 ± 5.6	0.011
KL-6 (U/ml), mean	596.3 ± 270.8	743.5 ± 413.8	0.583
AE risk score
Low risk	2	9	0.423
Intermediate risk	1	1	0.423
Combination of tumor location (initial/second)
Lower/Lower	3	3	0.070
Other	0	7	0.070
Combination of surgical procedure (initial/second)
Wedge/Wedge	0	2	0.296
Lobectomy/Sublobar	3	5
Other	0	3

^aCategorical data are expressed as numbers, and continuous data are expressed as means ± standard deviation
^bValues of p < 0.05 are significant
AE acute exacerbation, PY pack years, FEV1 forced expiratory volume in 1 s, VC vital capacity, KL-6 sialylated carbohydrate antigen KL-6

ISSN: 1471-2466