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Table 3 Genotype frequencies of rs6557421 in Nox3 gene among PH patients and controls

From: Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population

Genetic model Genotype Patients Controls Logistic regression Logistic regression (adjusted)
N = 109 (%) N = 99 (%) OR (95%CI) P-value ORc (95%CI) P-value
Codominant GG 30 (27.5) 48 (48.5) 1.00   1.00  
GT 12 (11) 41 (41.4) 0.47 (0.21–1.03) < 0.0001 0.22 (0.03–1.66) 0.0001
TT 67 (61.5) 10 (10.1) 10.72 (4.79–24.00) 9.66 (1.82–51.28)
Dominant GG 30 (27.5) 48 (48.5) 1   1.00  
GT/TT 79 (72.5) 51 (51.5) 2.48 (1.39–4.41) 0.0018 2.02 (0.53–7.74) 0.3
Recessive GG/GT 42 (38.5) 89 (89.9) 1.00   1.00  
TT 67 (61.5) 10 (10.1) 14.20 (6.65–30.33) < 0.0001 17.29 (3.60–83.02) 0.0001
Overdominant GG/TT 97 (89) 58 (58.6) 1.00   1.00  
GT 12 (11) 41 (41.4) 0.18 (0.09–0.36) < 0.0001 0.08 (0.01–0.48) 0.0013
  1. Bold-faced values indicate a significant difference at the 5% level; cadjusted by sex and age