Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population

Table 3 Genotype frequencies of rs6557421 in Nox3 gene among PH patients and controls

Genetic model	Genotype	Patients	Controls	Logistic regression		Logistic regression (adjusted)
Genetic model	Genotype	N = 109 (%)	N = 99 (%)	OR (95%CI)	P-value	OR^c (95%CI)	P-value
Codominant	GG	30 (27.5)	48 (48.5)	1.00		1.00
	GT	12 (11)	41 (41.4)	0.47 (0.21–1.03)	< 0.0001	0.22 (0.03–1.66)	0.0001
	TT	67 (61.5)	10 (10.1)	10.72 (4.79–24.00)	< 0.0001	9.66 (1.82–51.28)	0.0001
Dominant	GG	30 (27.5)	48 (48.5)	1		1.00
Dominant	GT/TT	79 (72.5)	51 (51.5)	2.48 (1.39–4.41)	0.0018	2.02 (0.53–7.74)	0.3
Recessive	GG/GT	42 (38.5)	89 (89.9)	1.00		1.00
Recessive	TT	67 (61.5)	10 (10.1)	14.20 (6.65–30.33)	< 0.0001	17.29 (3.60–83.02)	0.0001
Overdominant	GG/TT	97 (89)	58 (58.6)	1.00		1.00
Overdominant	GT	12 (11)	41 (41.4)	0.18 (0.09–0.36)	< 0.0001	0.08 (0.01–0.48)	0.0013

Bold-faced values indicate a significant difference at the 5% level; ^cadjusted by sex and age

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