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Table 2 Clinical factors, predisposing risk factors, severity factors, treatment factors, and outcome in the whole cohorta of patients with pleural infection according to initial antibiotic regimen

From: Pleural infection: a retrospective study of clinical outcome and the correlation to known etiology, co-morbidity and treatment factors

 

PENI

CEFU

Broad

Alla

*p-value

n=, (%)

125 (29)

215 (50)

89 (21)

429

 

Age (years)

61.4

63.9

60.7

62.6

0.12

Pneumonic (%)

90.4

89.8

88.8

89.7

0.12

Nosocomial (%)

8.8#

16.2#

15.7

14

0.09

Predisposing risk factors (%)

53.6#

70.7#

68.6

65.6

0.01

Antibiotics before hospital admittance (%)

40.8

45.6

42.7

43

0.62

Severely ill (%)

8.8

5.1

31.5

11.6

< 0.0001

Thoracocentesis delay, median /mean (days)

3 / 5.5

1 / 3.1

1 / 3.9

1 / 4.0

0.0003

Antibiotics before thoracocentesi (%)

87.2#

74.9#

77

77.6

0.24

Antibiotic treatment, median (days)

38.5

35

35.5

35

0.79

Pleural drainage delay > 2 days (%)

38.4

29.8

29.2

31.6

0.22

Fibrinolysis intrapleural (%)

32

30.7

28.1

30.2

0.96

ICU admittance (%)

4.8

1.9

21.3

6.6

< 0.0001

Mortality 30-day (%)

4.8

7.9

14.6

8.7

0.06

Mortality 90-day (%)

8

10.7

22.5

13

0.006

Surgery referral (%)

11.2

10.7

14.6

11.7

0.75

LOS, median

16

16

19

17

0.15

  1. a incl 13 patients with no successful thoracocentesis * comparing three treatment regimens. # = p < 0.05 for PENI vs CEFU