Table 2 Adaption from RA Floto, KN Olivier, L. Saiman et al.US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. Thorax; 2016:71:i1-i22; Haworth CS, Banks J, Capstick T et al. British Thoracic Society Guidelines for the Diagnosis and Management of Non-Tuberculous Mycobacterial Pulmonary Disease (NTM-PD). Thorax; 2017;72:2; Lallana EC and Fadul CE. Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases. Curr Neuropharmacol. 2011 Sep; 9 (3):468–477 [24]
Drug | Common Side Effects |
|---|---|
Amikacin | Nephrotoxicity, Ototoxicity: irreversible vestibulocochlear nerve damage. |
Azithromycin | Nausea, Vomiting, Diarrhoea, Fulminant Hepatitis, Pseudomembranous Colitis Ototoxicity Prolonged QT |
Clarithromycin | Hepatitis Taste Disturbance Prolonged QT |
Cefoxitin | Fever, Rash Eosinophilia, Anaemia, Leucopenia, Thrombocytopenia |
Clofazimine | Pink Brownish-Black Discoloration of Skin, Ichthyosis and dry skin Enteropathy, Nausea and Vomiting Conjunctival pigmentation, Dimness of vision and dry eyes. |
Co-Trimoxazole | Nausea, Vomiting, Diarrhoea Anaemia, Leucopenia, Thrombocytopenia Hyponatraemia, Hyperkalaemia Fever, Rash, Steven Johnson Syndrome |
Ethambutol | Optic Neuritis Hyperuricaemia Peripheral Neuropathy |
Imipenem | Rash and Urticaria Hepatitis, Nausea, Vomiting Diarrhoea |
Linezolid | Anaemia, Leucopenia, Thrombocytopenia Peripheral Neuropathy Optic Neuritis |
Moxifloxacin | Nausea, Vomiting, Diarrhoea Insomnia, Agitation, Anxiety Tendonitis Photosensitivity Prolonged QT |
Minocycline | Photosensitivity Nausea, Vomiting, Diarrhoea, Dysphagia Vertigo, Headache Skin Hyperpigmentation |
Rifampicin | Orange discoloration of bodily fluids Hepatitis, Nausea, Vomiting, Diarrhoea Fever, Chills Thrombocytopenia Renal Failure Increased hepatic metabolism of numerous drugs |
Streptomycin | Nephrotoxicity Ototoxicity |
Tigecycline | Nausea, Vomiting, Diarrhoea, Pancreatitis, Bilirubinaemia Increased risk of infections: sepsis/septic shock Hypoproteinaemia |
Corticosteroids | Cataract Increased risk of infection Type 2 Diabetes Mellitus Osteoporosis Gastrointestinal bleeding Altered Mood – rarely psychosis Proximal myopathy Hypertension |
Cyclophosphamide | Leucopenia Haemorrhagic Cystitis Infertility Long term increase risk of cancer e.g. Bladder Malignancy, Myeloproliferative disorders Nausea, Hair Loss, Skin Irritation |
Azathioprine | Hepatotoxicity, Pancreatitis Leucopenia Fatigue, Hair loss Diarrhoea Increased risk of malignancy |
Rituximab | Rash GI upset Serious Infection, CNS toxicity |