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Table 4 Prevalence of comorbidities during the 12-month baseline period for the newly diagnosed IPF cohorts

From: Characterizing idiopathic pulmonary fibrosis patients using US Medicare-advantage health plan claims data

  IPF Cohort (N= 4,716) IPF Diagnostic Testing Subgroup
(N= 2,518)
# of Patients with Condition During Baseline Prevalence (%) 95% CI # of Patients with Condition During Baseline Prevalence (%) 95% CI
Primary
 Acute Respiratory Worsening of Unknown Cause 126 2.7 2.2 - 3.1 126 5.0 4.2 - 5.9
 Pulmonary Hypertension 219 4.6 4.0 - 5.2 161 6.4 5.4 - 7.3
 Pulmonary Arterial Hypertension 10 0.2 0.1 - 0.3 5 0.2 0.0 - 0.4
 Lung Transplantation 10 0.2 0.1 - 0.3 2 0.1 0.0 - 0.2
 Lung Cancer 757 16.1 15.0 - 17.1 493 19.6 18.0 - 21.1
 Acute Myocardial Infarctiona 125 2.7 2.2 - 3.1 78 3.1 2.4 - 3.8
 Acute Myocardial Infarctionb 128 2.7 2.3 - 3.2 72 2.9 2.2 - 3.5
Secondary
 GI Perforation 11 0.2 0.1 - 0.4 6 0.2 0.0 - 0.4
 Chronic Renal Failure/Insufficiency 1,250 26.5 25.2 - 27.8 718 28.5 26.8 - 30.3
 Hemorrhagic Diathesis or Coagulopathy 120 2.5 2.1 - 3.0 80 3.2 2.5 - 3.9
 Venous Thrombosis 304 6.4 5.7 - 7.1 190 7.5 6.5 - 8.6
 Pulmonary Embolism 155 3.3 2.8 - 3.8 98 3.9 3.1 - 4.6
 Strokec 179 3.8 3.3 - 4.3 91 3.6 2.9 - 4.3
 Stroked 79 1.7 1.3 - 2.0 39 1.5 1.1 - 2.0
 Cardiac Arrhythmia 1,612 34.2 32.8 - 35.5 935 37.1 35.2 - 39.0
 Congestive Heart Failure 1,495 31.7 30.4 - 33.0 849 33.7 31.9 - 35.6
 Ischemic Heart Disease 1,906 40.4 39.0 - 41.8 1,073 42.6 40.7 - 44.5
 Arterial Hypertension 3,599 76.3 75.1 - 77.5 1,941 77.1 75.4 - 78.7
 Neutropenia 40 0.8 0.6 - 1.1 32 1.3 0.8 - 1.7
 Pneumonia 436 9.2 8.4 - 10.1 286 11.4 10.1 - 12.6
 Sepsis 245 5.2 4.6 - 5.8 150 6.0 5.0 - 6.9
 COPD 2,428 51.5 50.1 - 52.9 1,387 55.1 53.1 - 57.0
 GERD 1,321 28.0 26.7 - 29.3 761 30.2 28.4 - 32.0
 Type 2 Diabetes Mellitus 1,533 32.5 31.2 - 33.8 846 33.6 31.8 - 35.4
 Obstructive Sleep Apnea 383 8.1 7.3 - 8.9 224 8.9 7.8 - 10.0
 Bronchitis 1,911 40.5 39.1 - 41.9 1,098 43.6 41.7 - 45.5
 Upper Respiratory Tract Infection 451 9.6 8.7 - 10.4 266 10.6 9.4 - 11.8
 Pulmonary Rehabilitation 76 1.6 1.3 - 2.0 52 2.1 1.5 - 2.6
 Acute Coronary Syndrome 146 3.1 2.6 - 3.6 82 3.3 2.6 - 3.9
 Angina Pectoris 256 5.4 4.8 - 6.1 153 6.1 5.1 - 7.0
 Bleeding 567 12.0 11.1 - 13.0 319 12.7 11.4 - 14.0
 Major Bleeding (Upper GI) 75 1.6 1.2 - 1.9 40 1.6 1.1 - 2.1
 Major Bleeding (Lower GI) 312 6.6 5.9 - 7.3 180 7.1 6.1 - 8.2
 Hemorrhage of the Rectum or Anus 118 2.5 2.1 - 2.9 69 2.7 2.1 - 3.4
 Blood in Stool 127 2.7 2.2 - 3.2 62 2.5 1.9 - 3.1
 Epistaxis 120 2.5 2.1 - 3.0 71 2.8 2.2 - 3.5
 Hemorrhoids 106 2.2 1.8 - 2.7 57 2.3 1.7 - 2.8
 Hemorrhoids with Bleeding 30 0.6 0.4 - 0.9 16 0.6 0.3 - 0.9
 Intracranial Hemorrhage 39 0.8 0.6 - 1.1 19 0.8 0.4 - 1.1
 Acute Pancreatitis 47 1.0 0.7 - 1.3 27 1.1 0.7 - 1.5
 Hepatic Failure 14 0.3 0.1 - 0.5 7 0.3 0.1 - 0.5
 Acute Renal Failure 615 13.0 12.1 - 14.0 378 15.0 13.6 - 16.4
 Depression (MDD only) 575 12.2 11.3 - 13.1 315 12.5 11.2 - 13.8
 Depression (MDD and other) 648 13.7 12.8 - 14.7 355 14.1 12.7 - 15.5
  1. Optum Research Database – Medicare Advantage Population. Cohort Entry: 01 January 2008 - 30 September 2014
  2. Abbreviations: IPF idiopathic pulmonary fibrosis, CI confidence Interval, GI gastrointestinal, COPD chronic obstructive pulmonary disease, GERD gastroesophageal reflux disease, MDD major depressive disorder
  3. aPatients with 2+ claims with ICD-9 code of 410.x0 or 410.x1, primary position only. Patients with only one claim with these AMI codes but have claims suggestive of death were classified as AMI cases. Claims must be within 7 days of each other and must be from the inpatient or emergency room setting
  4. bPatients with an ICD-9-CM code for AMI (410.x0, 410.x1) in the principal (or primary) diagnosis position on at least one facility claim for hospitalization. Claims from emergency departments were not be included in the case identification as they are likely to lead to misclassification
  5. cICD-9 code 430, 431, 433.x1, or 434.x1, only in the primary or secondary diagnosis position. For patients identified by 430, 431, exclude if the following ICD-9 diagnosis codes are present on the same day: 800.xx-804.xx, 850.xx-854.xx (in any position); or V57.xx (in the primary position)
  6. dICD-9 code 430, 431, 433.x1 or 434.x1, restricted to the primary diagnosis position on at least 1 facility claim for hospitalization