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Table 4 Prevalence of comorbidities during the 12-month baseline period for the newly diagnosed IPF cohorts

From: Characterizing idiopathic pulmonary fibrosis patients using US Medicare-advantage health plan claims data

 

IPF Cohort (N= 4,716)

IPF Diagnostic Testing Subgroup

(N= 2,518)

# of Patients with Condition During Baseline

Prevalence (%)

95% CI

# of Patients with Condition During Baseline

Prevalence (%)

95% CI

Primary

 Acute Respiratory Worsening of Unknown Cause

126

2.7

2.2 - 3.1

126

5.0

4.2 - 5.9

 Pulmonary Hypertension

219

4.6

4.0 - 5.2

161

6.4

5.4 - 7.3

 Pulmonary Arterial Hypertension

10

0.2

0.1 - 0.3

5

0.2

0.0 - 0.4

 Lung Transplantation

10

0.2

0.1 - 0.3

2

0.1

0.0 - 0.2

 Lung Cancer

757

16.1

15.0 - 17.1

493

19.6

18.0 - 21.1

 Acute Myocardial Infarctiona

125

2.7

2.2 - 3.1

78

3.1

2.4 - 3.8

 Acute Myocardial Infarctionb

128

2.7

2.3 - 3.2

72

2.9

2.2 - 3.5

Secondary

 GI Perforation

11

0.2

0.1 - 0.4

6

0.2

0.0 - 0.4

 Chronic Renal Failure/Insufficiency

1,250

26.5

25.2 - 27.8

718

28.5

26.8 - 30.3

 Hemorrhagic Diathesis or Coagulopathy

120

2.5

2.1 - 3.0

80

3.2

2.5 - 3.9

 Venous Thrombosis

304

6.4

5.7 - 7.1

190

7.5

6.5 - 8.6

 Pulmonary Embolism

155

3.3

2.8 - 3.8

98

3.9

3.1 - 4.6

 Strokec

179

3.8

3.3 - 4.3

91

3.6

2.9 - 4.3

 Stroked

79

1.7

1.3 - 2.0

39

1.5

1.1 - 2.0

 Cardiac Arrhythmia

1,612

34.2

32.8 - 35.5

935

37.1

35.2 - 39.0

 Congestive Heart Failure

1,495

31.7

30.4 - 33.0

849

33.7

31.9 - 35.6

 Ischemic Heart Disease

1,906

40.4

39.0 - 41.8

1,073

42.6

40.7 - 44.5

 Arterial Hypertension

3,599

76.3

75.1 - 77.5

1,941

77.1

75.4 - 78.7

 Neutropenia

40

0.8

0.6 - 1.1

32

1.3

0.8 - 1.7

 Pneumonia

436

9.2

8.4 - 10.1

286

11.4

10.1 - 12.6

 Sepsis

245

5.2

4.6 - 5.8

150

6.0

5.0 - 6.9

 COPD

2,428

51.5

50.1 - 52.9

1,387

55.1

53.1 - 57.0

 GERD

1,321

28.0

26.7 - 29.3

761

30.2

28.4 - 32.0

 Type 2 Diabetes Mellitus

1,533

32.5

31.2 - 33.8

846

33.6

31.8 - 35.4

 Obstructive Sleep Apnea

383

8.1

7.3 - 8.9

224

8.9

7.8 - 10.0

 Bronchitis

1,911

40.5

39.1 - 41.9

1,098

43.6

41.7 - 45.5

 Upper Respiratory Tract Infection

451

9.6

8.7 - 10.4

266

10.6

9.4 - 11.8

 Pulmonary Rehabilitation

76

1.6

1.3 - 2.0

52

2.1

1.5 - 2.6

 Acute Coronary Syndrome

146

3.1

2.6 - 3.6

82

3.3

2.6 - 3.9

 Angina Pectoris

256

5.4

4.8 - 6.1

153

6.1

5.1 - 7.0

 Bleeding

567

12.0

11.1 - 13.0

319

12.7

11.4 - 14.0

 Major Bleeding (Upper GI)

75

1.6

1.2 - 1.9

40

1.6

1.1 - 2.1

 Major Bleeding (Lower GI)

312

6.6

5.9 - 7.3

180

7.1

6.1 - 8.2

 Hemorrhage of the Rectum or Anus

118

2.5

2.1 - 2.9

69

2.7

2.1 - 3.4

 Blood in Stool

127

2.7

2.2 - 3.2

62

2.5

1.9 - 3.1

 Epistaxis

120

2.5

2.1 - 3.0

71

2.8

2.2 - 3.5

 Hemorrhoids

106

2.2

1.8 - 2.7

57

2.3

1.7 - 2.8

 Hemorrhoids with Bleeding

30

0.6

0.4 - 0.9

16

0.6

0.3 - 0.9

 Intracranial Hemorrhage

39

0.8

0.6 - 1.1

19

0.8

0.4 - 1.1

 Acute Pancreatitis

47

1.0

0.7 - 1.3

27

1.1

0.7 - 1.5

 Hepatic Failure

14

0.3

0.1 - 0.5

7

0.3

0.1 - 0.5

 Acute Renal Failure

615

13.0

12.1 - 14.0

378

15.0

13.6 - 16.4

 Depression (MDD only)

575

12.2

11.3 - 13.1

315

12.5

11.2 - 13.8

 Depression (MDD and other)

648

13.7

12.8 - 14.7

355

14.1

12.7 - 15.5

  1. Optum Research Database – Medicare Advantage Population. Cohort Entry: 01 January 2008 - 30 September 2014
  2. Abbreviations: IPF idiopathic pulmonary fibrosis, CI confidence Interval, GI gastrointestinal, COPD chronic obstructive pulmonary disease, GERD gastroesophageal reflux disease, MDD major depressive disorder
  3. aPatients with 2+ claims with ICD-9 code of 410.x0 or 410.x1, primary position only. Patients with only one claim with these AMI codes but have claims suggestive of death were classified as AMI cases. Claims must be within 7 days of each other and must be from the inpatient or emergency room setting
  4. bPatients with an ICD-9-CM code for AMI (410.x0, 410.x1) in the principal (or primary) diagnosis position on at least one facility claim for hospitalization. Claims from emergency departments were not be included in the case identification as they are likely to lead to misclassification
  5. cICD-9 code 430, 431, 433.x1, or 434.x1, only in the primary or secondary diagnosis position. For patients identified by 430, 431, exclude if the following ICD-9 diagnosis codes are present on the same day: 800.xx-804.xx, 850.xx-854.xx (in any position); or V57.xx (in the primary position)
  6. dICD-9 code 430, 431, 433.x1 or 434.x1, restricted to the primary diagnosis position on at least 1 facility claim for hospitalization
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