Diagnostic yield and risk/benefit analysis of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients

Table 4 Final multidisciplinary diagnoses in patients undergoing trans-bronchial lung cryobiopsy (TLCB)

Multidisciplinary diagnosis	No. (%)
IPF	245 (35.1%) - 229 sporadic IPF - 16 familial IPF
CTD	50 (7.2%)
COP	47 (6.7%)
HP	45 (6.4%)
Sarcoidosis	39 (5.6%)
DIP/RB-ILD	36 (5.2%)
Malignancy	48 (6.9%) - 33 epithelial neoplasms - 15 lymphoproliferative disorders
iNSIP	28 (4.0%)
Follicular/Constrictive bronchiolitis	17 (2.4%)
Pneumonia	16 (2.3%)
DR-ILD	9 (1.3%)
Aspiration/lipid pneumonia	7 (1.0%)
LCH	7 (1.0%)
Silicosis	6 (0.9%)
iPPFE	6 (0.9%)
CEP	5 (0.7%)
AFOP	4 (0.6%)
Other	15 (2.1%) - 3 GVHD - 2 lymphoid nodular hyperplasia in CVID - 2 GL-ILD - 2 alveolar proteinosis - 1 DAD - 1 DIPNECH - 1 ACFE - 1 ECD - 1 vasculitis - 1 asthma
ND	69 (9.9%)

Abbreviations: IPF Idiopathic pulmonary fibrosis, CTD Connective tissue disease, COP Cryptogenic organizing pneumonia, HP Hypersensitivity pneumonitis, RB-ILD Respiratory bronchiolitis-interstitial lung disease, iNSIP Idiopathic, NSIP Non-specific interstitial pneumonia, DR-ILD Drug-related interstitial lung disease, LCH Langerhans cell histiocytosis, iPPFE Idiopathic pleuro-parenchymal fibroelastosis, CEP Chronic eosinophilic pneumonia, AFOP Acute fibrinous organizing pneumonia, GVHD Graft versus host disease, CVID Common variable immune-deficiency, GL-ILD Granulomatous lymphocytic-interstitial lung disease, DAD Diffuse alveolar damage, ACFE Airway-centered fibroelastosis, ECD Erdheim Chester disease

ISSN: 1471-2466