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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

Fig. 1

Effects of miR-193a on Beclin1, p-Akt, and LC3-II levels and autophagy in A549 cells. a Quantification of the percentage of A549 cells with GFP-LC3 puncta in cells that were transfected with miR-193a mimic, inhibitor or scrambled sequences. b MiR-193a levels in A549 cells that were transfected with miR-193a mimic, inhibitor or scrambled sequences. c-f Representative statistical analyses and graphs of mTOR, Akt, p-Akt, p-mTOR, Beclin1 and LC3-II levels by western blotting in A549 cells that were transfected with miR-193a mimic, inhibitor or scrambled sequences. Data that were obtained from quantitative densitometry are presented as the mean ± SEM of three independent experiments. *p < 0.05 vs. controls and treatment groups. #p < 0.05 vs. controls

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BMC Pulmonary Medicine

ISSN: 1471-2466

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