Table 4 Diagnostic performance of bronchoalveolar lavage fluid NK, NKT and CD8+ cells in diagnosing hypersensitivity pneumonitis
From: NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis
Lymphocyte populations | AUC-ROC (95%CI) | Maximum Youden’s index cut-off | Sensitivity - % (95%CI) | Specificity - % (95%CI) | PPV - % (95%CI) | NPV - % (95%CI) |
|---|---|---|---|---|---|---|
NK (cells/mL) | 0.76 (0.69–0.84) | 3446 | 47 (40–54) | 92 (88–96) | 68 (62–74) | 83 (78–88) |
NK (%) | 0.70 (0.62–0.79) | 1.4 | 77 (71–83) | 55 (48–62) | 37 (30–44) | 85 (80–90) |
NKT (cells/mL) | 0.73 (0.65–0.82) | 1678 | 75 (69–81) | 65 (58–72) | 42 (35–49) | 88 (84–93) |
NKT (%) | 0.58 (0.49–0.68) | 6.1 | 40 (33–47) | 88 (84–93) | 39 (33–46) | 79 (73–85) |
CD8+ (cells/mL) | 0.71 (0.62–0.80) | 40,671 | 47 (40–54) | 88 (84–93) | 59 (52–66) | 82 (77–87) |
CD8+ (%) | 0.63 (0.54–0.72) | 28.7 | 65 (58–72) | 61 (54–68) | 39 (33–46) | 84 (79–89) |