Table 2 Inclusion and exclusion criteria

Inclusion Criteria

• Age 18 years or older

• Standard eligibility criteria for non-palliative LTOT at rest: [1, 2]

o PaO2 < 7.4 kPa or oxygen saturation < 88% breathing air, or

o PaO2 < 8.0 kPa on air and either signs of heart failure or polycythemia (EVF > 0.54)

Exclusion Criteria

• Standard contraindications for LTOT

• Smoking or contact with open fire

• Other inability to safely comply with LTOT

• Already on LTOT for more than 4 weeks

• Inability to comply with any of the study interventions (LTOT 15 h /day or 24 h/ day) as judged by the responsible oxygen staff

• Opt out from being registered in Swedevox

• Inability to give informed written consent to participate in the study as judged by the responsible oxygen staff

• Lack of Swedish identification number

• Previous participation in the study