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Table 1 Basic characteristics of enrolled studies

From: The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Study

Study design

Country

population

NCT.no

Disease

PaO2/ABG

Time of assessment

Cutoff value

Comparator group

Outcome measure reported

Asfar 2017 [36]

Multicenter randomised study

France

442

NCT 01722422

Septic shock

During first 24 h

First 24 h

FiO2 1.0

SaO2 88~95%

28-day mortality

Asher 2013 [16]

Retrospective study

USA

193

NR

traumatic brain injury

HighestPaO2

First 72 h

≧200 mmHg

Not exposed to hyperoxia

In-hospital mortality

Bellomo 2011 [20]

Retrospective study

Australia

12,108

NR

cardiac arrest

Worst PaO2

First 24 h

≧300 mmHg

Normoxia

In-hospital mortality

Brenner 2012 [25]

Retrospective study

USA

1547

NR

traumatic brain injury

Mean PaO2

First 24 h

> 200 mmHg

Normoxia

In-hospital mortality

Davis 2009 [17]

Retrospective study

USA

3420

NR

traumatic brain injury

First PaO2

On arrival

> 487 mmHg

Not exposed to hyperoxia

In-hospital mortality

de Jonge 2008 [12]

Retrospective study

Dutch

3322

NR

Mixed

Worst PaO2

First 24 h

≥120 mmHg (upper quintile)

PaO2 between 66 and 80 mmHg

In-hospital mortality

Eastwood 2012 [19]

Retrospective study

Australia

152,680

NR

Mixed

Worst PaO2

First 24 h

≧305 mmHg (upper decile) for adjusted analysis

PaO2 between 75 and 85 mmHg

In-hospital mortality

Elmer 2015 [14]

Reteospective study

USA

184

NR

cardiac arrest

During first 24 h

First 24 h

PaO2 > 100 mmHg

PaO2 between 60 and 100 mmHg

In-hospital mortality

Fujita 2017 [27]

Reteospective study

Japan

 

NCT00134472

traumatic brain injury

First PaO2

First 24 h

NR

NR

In-hospital mortality

Helmerhors 2015 [21]

Cohort study

Dutch

5258

NR

cardiac arrest

Worst PaO2

First 24 h

PaO2 > 300 mmHg

PaO2 between 60 and 300 mmHg

In-hospital mortality

Helmerhors 2017 [33]

Observational cohort study

Netherland

14,441

NR

post cardiac surgery

Worst PaO2

First 24 h

≧200 mmHg

PaO2 between 60 and 120 mmHg

In-hospital mortality

Ihle 2013 [15]

Retrospective study

Australia and New Zealand

584

NR

cardiac arrest

Worst PaO2

First 24 h

≧300 mmHg

Normoxia

In-hospital mortality

Janz 2012 [22]

Retrospective study

USA

170

NR

cardiac arrest

Highest PaO2

First 24 h

≧300 mmHg

Not exposed to hyperoxia

In-hospital mortality

Kilgannon 2011 [23]

Retrospective study

USA

4459

 

cardiac arrest

First PaO2

First 24 h

≧300 mmHg

Not exposed to hyperoxia

In-hospital mortality

LÃ¥ng 2016 [31]

Retrospective study

Finland

432

NR

hemorrhage

Mean PaO2

First 24 h

≧150 mmHg

PaO2 between 97.5 and 150 mmHg

3 months mortality

Lee 2014 [24]

Retrospective study

Korea

213

NR

cardiac arrest

Mean PaO2

From return of spontaneous circulation to the end of therapeutic hypothermia

≧156.7 mmHg (upper quartile)

PaO2 between 116 and 134.9 mmHg (second quartile)

In-hospital mortality

Munshi 2017 [34]

Retrospetive study

Canada

1952

NR

ECMO

First PaO2after 24 h

First 24 h

> 100 mmHg

PaO2 between 60 and 100 mmHg

In-hospital mortality

Page 2018 [13]

Observational cohort study

USA

668

NR

Mixed

Highest PaO2

After intubation

PaO2 > 120 mmHg

PaO2 between 60 and 120 mmHg

In-hospital mortality

Raj 2013 [26]

Retrospective study

Finland

1116

NR

traumatic brain injury

Worst PaO2

First 24 h

> 100 mmHg

Normoxia

In-hospital mortality

Rincon 2014 [28]

Multicenter cohort study

USA

1212

NR

traumatic brain injury

First PaO2

First 24 h

≧300 mmHg

Normoxia

In-hospital mortality

Rincon 2014 [29] CCM

Multicenter cohort study

USA

2894

NR

Stroke

First PaO2

First 24 h

≧300 mmHg

Normoxia

In-hospital mortality

Russel 2017 [35]

Prospectively study

USA

653

NR

traumatic injuries

Highest PaO2

First 24 h

NR

NR

In-hospital mortality

Sutton 2014 [32]

Retrospective study

Australia and New Zealand

83,060

NR

post cardiac surgery

Worst PaO2

First 24 h

≧300 mmHg

PaO2 between 60 and 300 mmHg

In-hospital mortality

Young 2012 [30]

Retrospective cohort stucy

Australia and New Zealand

2643

NR

stroke

Worst PaO2

First 24 h

≧341 mmHg (upper quartile)

Normoxia(PaO2 > 69 and < 341 mmHg, 2nd to 9th deciles)

In-hospital mortality

  1. FiO2 inspired oxygen fraction, PaO2 arterial partial pressure of oxygen, SaO2 saturation of oxygen