Fig. 4
From: Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
a Network analysis using the top 100 genes whose expression correlates with HOTTIP levels. The Induced Network Module Analysis tool from Consensus PathDB was used. b DIANA-miRPath analysis using the miRNAs whose expression correlates with HOTTIP levels. DIANA-mirPath is a miRNA pathway analysis web-server that examines a list of miRNAs provided by the user, identifies their potential/validated targets, and performs a pathway analysis to identify the most relevant pathways regulated by the miRNAs. In the present study, experimentally validated miRNA interactions derived from DIANA-Tarbase and KEGG analysis were used in the analysis. The KEGG signaling pathways identified are ordered from left to right in descending order of p-value. The y-axis indicates the number of genes (dark blue) and miRNAs (light blue) identified in the miRNA/target interaction analysis which are included in each KEGG pathway identified. For example, the Hippo signaling pathway is the most significant pathway identified and included 28 miRNAs from the HOTTIP-related miRNA signature, which targets 86 genes included in the Hippo signaling pathway