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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats

Fig. 5

UA alleviated CSE-induced TGF-β1/Smad2.3 pathway proteins and S100A4 expression in HBEs and HUVECs in vitro. A Western blot analyses showed UA attenuated CSE-induced TGF-β1/Smad2.3 pathway protein and S100A4 expression in HBEs. B IOD of TGF-β1/smad2.3 pathway, IGF1, and S100A4 expression in HBEs

#p < 0.05 vs. Sham; *p < 0.05 vs. CSE. C Western blot analyses showed that UA alleviated CSE-induced TGF-β1/Smad2.3 and S100A4 protein expression in HUVECs. D IOD of TGF-β1/Smad2.3 pathway proteins and S100A4 expression in HUVECs. #p < 0.05 vs. Sham; *p < 0.05 vs. CSE. UA: ursolic acid; CSE: cigarette smoke extract (group); HBE: Human Bronchial Epithelial cells; HUVEC: Human Umbilical Vein Endothelial Cells; IOD: integral optical density.

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BMC Pulmonary Medicine

ISSN: 1471-2466

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