Table 1 Patient characteristics
|  | All (n = 48) | Bev group (n = 17) | Non-Bev group (n = 31) | p value |
|---|---|---|---|---|
Age (years) | 67.5 (65.0–73.0) | 67.0 (66.0–73.0) | 68.0 (66.5–73.0) | 0.75 |
Sex (male, %) | 40 (83.3) | 17 (100) | 23 (74.2) | 0.038 |
Smoking status | Â | Â | Â | 0.08 |
 Current or former | 42 (87.5) | 17 (100) | 25 (80.6) |  |
 Never | 6 (12.5) | 0 (0) | 6 (19.4) |  |
 Previous steroid therapy | 6 (12.5) | 2 (11.8) | 4 (12.9) | 1.00 |
ECOG PS | Â | Â | Â | 0.37 |
 0–1 | 40 (83.3) | 13 (76.5) | 27 (87.1) |  |
 ≥2 | 8 (16.7) | 4 (23.5) | 4 (12.9) |  |
Stage | Â | Â | Â | 1.00 |
 III | 9 (18.7) | 3 (17.6) | 6 (19.4) |  |
 IV | 39 (81.3) | 14 (82.4) | 25 (80.6) |  |
Classification of ILD | Â | Â | Â | 1.00 |
 IIPs | 45 (93.7) | 16 (94.1) | 29 (93.5) |  |
 Non-IIPs | 3 (6.3) | 1 (5.9) | 2 (6.5) |  |
ILD pattern | Â | Â | Â | 1.00 |
 UIP pattern | 24 (50.0) | 9 (52.9) | 15 (48.4) |  |
 Non-UIP pattern | 24 (50.0) | 8 (47.1) | 16 (51.6) |  |
SpO2 at rest (%) | 96.0 (96.0–97.0) | 96.0 (95.0–97.0) | 96.0 (96.0–97.0) | 0.43 |
FVC (% predicted) | 88.5 (79.5–100) | 87.5 (78.5–99.5) | 90.0 (81.0–100) | 0.85 |
LDH (U/L) | 220.0 (194.8–254.0) | 228.0 (205.0–253.0) | 211.0 (194.5–252.5) | 0.48 |
KL-6 (U/ml) | 800.0 (518.5–1190.0) | 828.5 (591.0–1311.0) | 778.0 (454.0–1120.0) | 0.27 |
CRP (mg/dl) | 0.9 (0.3–2.0) | 0.9 (0.7–2.3) | 0.9 (0.2–1.2) | 0.44 |
First-line regiments | Â | Â | Â | 0.96 |
 CDDP + PEM | 11 (22.9) | 4 (23.5) | 7 (22.6) |  |
 CBDCA + PEM | 25 (52.1) | 10 (58.8) | 15 (48.3) |  |
 PEM | 4 (8.3) | 1 (5.9) | 3 (9.7) |  |
 CBDCA + PTX | 8 (16.7) | 2 (11.8) | 6 (19.4) |  |
 PEM-containing regiments | 40 (83.3) | 15 (88.2) | 25 (80.6) | 0.69 |
 First-line related AE-ILD | 7 (14.5) | 0 (0) | 7 (22.6) | 0.041 |