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Table 1 Patient characteristics

From: Negative impact of anorexia and weight loss during prior pirfenidone administration on subsequent nintedanib treatment in patients with idiopathic pulmonary fibrosis

  Present study (n = 30) Nintedanib group in INPULSIS trials
Japanese (n = 76) Overall (n = 638)
Baseline characteristics
 Age 72.0 [68.0, 74.8] 68.4 ± 7.6a 66.6 ± 8.1a
 Gender (male/female) 24/6 62/14 507/131
 Current or former smoker (%) 26 (86.7%) 66 (86.8%) 464 (72.7%)
 Physique
  Body weight (kg) 54.9 [49.7, 64.4] 63.8 ± 11.6a 79.2 ± 16.6a
  Body mass index 21.0 [19.0, 23.6] 24.4 ± 3.4a 28.1 ± 4.6a
  Body surface area (DuBois, m2) 1.59 [1.48, 1.72]
 Concomitant therapy
  Prednisolone (%) 3 (10.0%) 9 (11.8%) 136 (21.3%)
  Tacrolimus (%) 1 (3.3%) 0 0
 Laboratory data
  Aspartate aminotransferase (IU/L) 21.5 [18.0, 24.8]
  Alanine aminotransferase (IU/L) 16.0 [11.0, 24.3]
  Total bilirubin (mg/dL) 0.50 [0.30, 0.60]
  γ-glutamyl transpeptidase (IU/L) 31.0 [21.3, 48.0]
  Creatinine (mg/dL) 0.80 [0.68, 0.87]
  Krebs von den Lungen-6 (U/mL) 1021 [829, 1903]
  Surfactant protein D (ng/dL) 382 [259, 452]
 Lung function test
 Forced vital capacity (L) 1.68 [1.34, 1.99] 2.42 ± 0.67a 2.71 ± 0.76a
  % Forced vital capacity (%) 52.9 [43.7, 69.7] 80.9 ± 16.6a 79.7 ± 17.6a
 % DLco (%) 44.2 [40.9, 58.5] 44.6 ± 11.4a 47.4 ± 13.5a
Administration history of pirfenidone
 Administration period (months) 8.30 [4.23, 13.9]
 Time from discontinuation to nintedanib initiation    
  0 (direct switch) 20 (66.6%)
  < 1 month 3 (10.0%)
  ≥ 1 month 7 (23.3%)
 Reason for discontinuation (%)
  Decline of FVC 15 (50.0%)
 Adverse events 15 (50.0%)
 Maintenance dose (%)
  < 1200 mg 10 (33.3%)
  1200 mg 16 (53.3%)
  1800 mg 4 (13.3%)
  1. Categorical data are presented as numbers (percentages) and continuous data are presented as medians (interquartile ranges)
  2. Abbreviation: DLco diffusing capacity for lung carbon monoxide
  3. aContinuous data in INPULSIS trials are presented as the mean ± standard deviation