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Table 3 Clinical characteristics of patients with idiopathic pulmonary fibrosis and a main pulmonary artery to aorta diameter ratio ≤ 0.8 and > 0.8

From: Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis

Clinical factors mPA/Ao ratio Univariate analysis Multivariate analysis
≤ 0.8 (n = 121) > 0.8 (n = 182) OR 95% CI P OR 95% CI P
Age, years 68.7 ± 8.3 66.1 ± 10.0 0.97 0.95–1.00 0.019 0.96 0.91–1.01 0.136
Sex, male 102 (84.3%) 132 (72.5%) 2.03 1.13–3.66 0.018    
BMI, kg/m2, (median, IQR) 23.2 (20.8–26.6) 22.4 (19.8–24.8) 0.96 0.91–1.03 0.247    
Ever-smoker 91 (75.8%) 120 (66.3%) 0.63 0.37–1.05 0.078    
Underlying disease
 Hypertension 40 (33.1%) 60 (33.0%) 1.00 0.61–1.62 0.987    
 Diabetes mellitus 30 (24.8%) 58 (31.9%) 1.42 0.85–2.38 0.185    
 Pulmonary tuberculosis 15 (12.4%) 28 (15.4%) 1.29 0.66–2.52 0.466    
 Emphysema 19 (15.7%) 20 (11.0%) 0.67 0.34–1.31 0.240    
 Ischemic heart disease 8 (6.6%) 21 (11.5%) 1.84 0.79–4.31 0.158    
 Congestive heart failure 2 (1.7%) 8 (4.4%) 2.74 0.57–13.1 0.208    
GAP score 3.07 ± 1.16 3.24 ± 1.31 1.12 0.91–1.37 0.280    
6 MW distance, m (median, IQR) 415.0 (356.3–477.5) 400.0 (246.3–480.0) 0.99 0.99–1.00 0.107    
PFT at diagnosis
 FVC, % predicted, (median, IQR) 77.0 (63.0–90.5) 71.0 (55.0–83.0) 0.98 0.96–0.99 < 0.001 1.01 0.97–1.05 0.735
 FEV1, % predicted, (median, IQR) 94.0 (76.0–101.0) 83.0 (66.0–98.5) 0.98 0.97–0.99 < 0.001 1.01 0.97–1.04 0.805
 DLCO, % 77.1 ± 23.6 62.7 ± 23.6 0.97 0.96–0.99 < 0.001 0.97 0.95–0.99 0.002
Echocardiography
 EF, %, (median, IQR) 64.0 (60.0–69.0) 66.0 (62.0–70.0) 1.02 0.99–1.05 0.294 1.16 0.93–1.45 0.187
 RVP, mmHg, (median, IQR) 34.4 (25.0–43.0) 40.0 (31.5–48.0) 1.03 1.00–1.05 0.038 1.01 0.98–1.05 0.485
Chest CT
 mPA diameter, mm, (median, IQR) 26.3 (24.5–27.9) 29.7 (27.1–31.9) 1.49 1.34–1.65 < 0.001    
 Ascending aorta diameter,
mm, (median, IQR)
35.7 (33.9–37.7) 32.7 (30.4–35.0) 0.75 0.69–0.82 < 0.001    
  1. The data are presented as the number (percentage) unless otherwise indicated. 6MWD, 6-min walking distance
  2. Ao aorta, CT computed tomography, DLCO diffusing capacity, EF ejection fraction, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, IQR interquartile range, mPA main pulmonary artery, PFT pulmonary function test, RVP right ventricular pressure