Table 3 Clinical characteristics of patients with idiopathic pulmonary fibrosis and a main pulmonary artery to aorta diameter ratio ≤ 0.8 and > 0.8
Clinical factors | mPA/Ao ratio | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
≤ 0.8 (n = 121) | > 0.8 (n = 182) | OR | 95% CI | P | OR | 95% CI | P | |
Age, years | 68.7 ± 8.3 | 66.1 ± 10.0 | 0.97 | 0.95–1.00 | 0.019 | 0.96 | 0.91–1.01 | 0.136 |
Sex, male | 102 (84.3%) | 132 (72.5%) | 2.03 | 1.13–3.66 | 0.018 |  |  |  |
BMI, kg/m2, (median, IQR) | 23.2 (20.8–26.6) | 22.4 (19.8–24.8) | 0.96 | 0.91–1.03 | 0.247 |  |  |  |
Ever-smoker | 91 (75.8%) | 120 (66.3%) | 0.63 | 0.37–1.05 | 0.078 |  |  |  |
Underlying disease | ||||||||
 Hypertension | 40 (33.1%) | 60 (33.0%) | 1.00 | 0.61–1.62 | 0.987 |  |  |  |
 Diabetes mellitus | 30 (24.8%) | 58 (31.9%) | 1.42 | 0.85–2.38 | 0.185 |  |  |  |
 Pulmonary tuberculosis | 15 (12.4%) | 28 (15.4%) | 1.29 | 0.66–2.52 | 0.466 |  |  |  |
 Emphysema | 19 (15.7%) | 20 (11.0%) | 0.67 | 0.34–1.31 | 0.240 |  |  |  |
 Ischemic heart disease | 8 (6.6%) | 21 (11.5%) | 1.84 | 0.79–4.31 | 0.158 |  |  |  |
 Congestive heart failure | 2 (1.7%) | 8 (4.4%) | 2.74 | 0.57–13.1 | 0.208 |  |  |  |
GAP score | 3.07 ± 1.16 | 3.24 ± 1.31 | 1.12 | 0.91–1.37 | 0.280 |  |  |  |
6 MW distance, m (median, IQR) | 415.0 (356.3–477.5) | 400.0 (246.3–480.0) | 0.99 | 0.99–1.00 | 0.107 |  |  |  |
PFT at diagnosis | ||||||||
 FVC, % predicted, (median, IQR) | 77.0 (63.0–90.5) | 71.0 (55.0–83.0) | 0.98 | 0.96–0.99 | < 0.001 | 1.01 | 0.97–1.05 | 0.735 |
 FEV1, % predicted, (median, IQR) | 94.0 (76.0–101.0) | 83.0 (66.0–98.5) | 0.98 | 0.97–0.99 | < 0.001 | 1.01 | 0.97–1.04 | 0.805 |
 DLCO, % | 77.1 ± 23.6 | 62.7 ± 23.6 | 0.97 | 0.96–0.99 | < 0.001 | 0.97 | 0.95–0.99 | 0.002 |
Echocardiography | ||||||||
 EF, %, (median, IQR) | 64.0 (60.0–69.0) | 66.0 (62.0–70.0) | 1.02 | 0.99–1.05 | 0.294 | 1.16 | 0.93–1.45 | 0.187 |
 RVP, mmHg, (median, IQR) | 34.4 (25.0–43.0) | 40.0 (31.5–48.0) | 1.03 | 1.00–1.05 | 0.038 | 1.01 | 0.98–1.05 | 0.485 |
Chest CT | ||||||||
 mPA diameter, mm, (median, IQR) | 26.3 (24.5–27.9) | 29.7 (27.1–31.9) | 1.49 | 1.34–1.65 | < 0.001 |  |  |  |
 Ascending aorta diameter, mm, (median, IQR) | 35.7 (33.9–37.7) | 32.7 (30.4–35.0) | 0.75 | 0.69–0.82 | < 0.001 |  |  |  |