Table 3 The diagnostic accuracy of the serum biomarkers for distinguishing PPE from transudates or noninfectious exudates
Serum | Cutoff | Sensitivity (%) | Specificity (%) | AUC (95% confidence interval) |
|---|---|---|---|---|
PPE vs. transudates | ||||
NGAL | > 101.9 ng/ml | 82.1 | 100.0 | 0.953 (0.906–1.000) |
Calprotectin | > 2.6 μg/ml | 78.2 | 100.0 | 0.907 (0.842–0.971) |
BPI | > 88.5 pg/ml | 80.8 | 100.0 | 0.904 (0.842–0.967) |
CRP | > 7.9 mg/dl | 81.6 | 72.7 | 0.861 (0.765–0.957) |
IL-6 | > 12.6 pg/ml | 89.7 | 72.7 | 0.865 (0.759–0.970) |
PPE vs. noninfectious exudates | ||||
NGAL | > 106.9 ng/ml | 80.8 | 100.0 | 0.947 (0.907–0.987) |
Calprotectin | > 2.5 μg/ml | 79.5 | 100.0 | 0.905 (0.848–0.962) |
BPI | > 113 pg/ml | 73.1 | 90.9 | 0.861 (0.780–0.942) |
CRP | > 8.5 mg/dl | 80.3 | 72.7 | 0.831 (0.744–0.918) |
IL-6 | > 25.4 pg/ml | 71.8 | 63.6 | 0.685 (0.545–0.825) |