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Table 1 Baseline characteristics of patients treated with antifibrotic agents

From: Acute exacerbation of chronic fibrosing interstitial pneumonia in patients receiving antifibrotic agents: incidence and risk factors from real-world experience

Factor

Group

Overall

(n = 100)

Age

68 [64, 73]

 Age ≥ 65 yrs. (%)

Yes

73 (73.0)

 Sex (%)

Male

75 (75.0)

 Smoking history (%)

Yes

69 (69.0)

 Clinical diagnosis

IPF

75 (75)

 

others

25 (25)

 SLB (%)

Yes

29 (29.0)

 Commodity index

 

1.0 [1.0, 1.0]

 TTE RVSP

≥40 mmHg

29 (29.0)

 FVC % predicted

 

70.8 [58.7, 82.4]

 FVC % predicted < 70

Yes

48 (48.0)

 DLCO % predicted

 

55.9 [45.1, 68.4]

 DLCO % predicted < 55

Yes

45(45.0)

 ILD-GAP score

 

3 [2, 4]

 ILD-GAP score

0–3

61 (61.0)

 

4–5

31 (31.0)

6–8

8 (8.0)

 LTOT

No use

63 (63.0)

 

Introduce at same time

29 (29.0)

Prior to antifibrotic agent

8 (8.0)

 KL6

 

1265 [804, 2046]

 LDH

239.5 [208, 265]

 Time from diagnosis to antifibrotic agent (per month)

12 [6, 36]

Medication

 Antifibrotic agent

Nintedanib

52 (52.0)

 

Pirfenidone

48 (48.0)

 H2 blocker use

Yes

12 (12)

 PPI use

Yes

62 (62)

 Corticosteroid use

Yes

26 (26)

 Corticosteroid dose

mg/body/day

0 [0, 5]

 Corticosteroid dose in patients receiving corticosteroids

Mg/body/day

10[10, 20]

 Anticoagulant (%)

Yes

18 (18.0)

  1. No (%), median [IQR]
  2. IPF idiopathic pulmonary fibrosis, SLB surgical lung biopsy, TTE transthoracic echocardiogram, RVSP right ventricular systolic pressure, FVC forced vital capacity, DLCO carbon monoxide diffusing capacity of the lungs, ILD-GAP interstitial lung disease subtype, gender, age, and two lung physiology variables, LTOT Long-term oxygen therapy, PPI proton pump inhibitor, LDH lactate dehydrogenase