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Table 2 Results of included randomized controlled trials

From: Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis

Trials

(country, start year)

No.

randomized

Age (y)

[mean ± SD or median (IQR)]

Male

(%)

Active smokers

(%)

Pack-years

[mean ± SD or median (IQR)]

Lung cancer mortality

[RR (95% CI)]

All-cause mortality

[RR (95% CI)]

Early detection (stage I) rates

[RR (95% CI)]

Major complicationsa after invasive proceduresb

[RR (95% CI) or death number / total number of procedures]

Death after invasive proceduresb

[RR (95% CI) or event number / total number of procedures]

DANTE

(Italy, 2001)

2472

64.0 (5)

100

56.9

45.0 (28.5)

1.01 (0.70–1.44)

0.96 (0.79–1.16)

2.03* (1.26–3.29)

NR

0.75 (0.07–8.02)

DLCST

(Denmark, 2004)

4104

57.9 ± 4.8

55.2

76.1

36.4 ± 13.4

1.03 (0.66–1.60)

1.01 (0.82–1.25)

3.31* (1.70–6.46)

LDCT: 4/49

LDCT: 0/49

ITALUNG

(Italy, 2004)

3206

60.9

64.7

64.8

40 (NR)

0.71 (0.48–1.04)

0.84 (0.69–1.03)

3.18* (1.54–6.58)

NR

LDCT: 6/76

LSS

(USA, 2000)

3318

Range: 55–74

58.6

57.5

54 (NR)

1.23 (0.74–2.05)

1.20 (0.94–1.52)

1.19* (0.63–2.22)

NR

NR

LUSI

(Germany,2007)

4052

58.0 (5)

64.7

61.9

36 (18)

All: 0.72 (0.45–1.16)

Female: 0.31* (0.10–0.94)

Male: 0.92 (0.54–1.58)

0.98 (0.79–1.22)

Female: 0.82 (0.47–1.42)

Male: 1.02 (0.80–1.29)

NR

NR

NR

MILD

(Italy, 2005)

4099

Annual: 57 (NR)

Biennial: 58 (NR)

66.3

77.5

Annual: 39 (NR)

Biennial: 39 (NR)

0.73 (0.47–1.12)

0.94 (0.73–1.20)

2.31* (1.37–3.88)

NR

NR

NELSON

(Netherlands, Belgium, 2003)

15,822

58.0 (8)

83.6

55.4

38.0 (19.8)

Female: 0.61 (0.35–1.06)

Male: 0.74* (0.60–0.91)

NR

NR

NR

NR

NLST

(USA, 2002)

53,454

61 ± 5

59

48.2

48 (27)

0.85* (0.75–0.96)

0.94 (0.88–1.00)

1.32* (1.15–1.52)

1.30 (0.84–2.04)

0.60 (0.27–1.31)

Yang 2018

(China, 2013)

6717

59.8 ± 5.8

46.8

21.5

12.8 ± 17.2 (M)

9.1 ± 10.7 (F)

0.18 (0.01–3.72)

NR

4.71* (1.36–16.29)

NR

LDCT: 0/60

  1. Abbreviations: CI Confidence interval, IQR Interquartile range, NR Not reported, RR Risk ratio, SD Standard deviation; see Table 1 legends for expansion of other abbreviations
  2. *: Statistically significant differences
  3. aMajor complications included: death, anaphylaxis, cardiac arrest, cerebral vascular accident/stroke, congestive heart failure, myocardial infarction, intervention-required thromboembolic complications, acute respiratory failure, respiratory arrest, bronchial stump leak requiring tube thoracostomy or other drainage for > 4 days, bronchopulmonary fistula, empyema, prolonged mechanical ventilation > 48 h postoperatively, tube placement-required hemothorax, brachial plexopathy, lung collapse, chylous fistula, injury to vital organ or vessel, wound dehiscence, and infarcted sigmoid colon
  4. bInvasive procedures included: surgery, biopsy, bronchoscopy or fine needle aspiration cytology
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BMC Pulmonary Medicine

ISSN: 1471-2466

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