Fig. 3

Mean observed change in PASP and FVC between IPF patients with LTOT and without LTOT. a The values of mean pulmonary artery systolic pressure (PASP) changes after nintedanib treatment in idiopathic pulmonary fibrosis (IPF) patients with (solid line) and without (dotted line) long-term oxygen treatment (LTOT). Mean PASP increases were 8.24 mmHg and 2.84 mmHg, respectively. There was a significant increase in the value of the mean PASP 48 weeks after nintedanib relative to baseline in IPF patients with LTOT (P = 0.001). b The values of mean forced vital capacity (FVC) changes after nintedanib treatment in IPF patients with (solid line) and without (dotted line) LTOT. mean FVC decreases were 224 mL and 270 mL, respectively. There were no significant decreases in the mean FVC relative to baseline in either group (P = 0.188 and P = 0.314). Changes in the value of the mean PASP and FVC from baseline to 48 weeks after nintedanib treatment were assessed using a paired t-test. Two-sided P-values < 0.05 were considered significant