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Table 1 Baseline patient characteristics

From: Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study

Variable

n

All (n = 359)

SSc (n = 207)

RA (n = 45)

MCTD (n = 26)

Other (n = 81)a

Age at first visit, y

357

56 ± 13

55 ± 13

62 ± 14

49 ± 12

58 ± 12

Male, n (%)

359

81 (23)

40 (19)

10 (22)

3 (12)

28 (35)

Ethnicity, n (%)

357

     

 Caucasian

 

223 (63)

143 (69)

22 (50)

12 (46)

46 (57)

 Asian

 

62 (17)

28 (14)

5 (11)

9 (35)

20 (25)

 South Asian

 

33 (9)

17 (8)

8 (18)

2 (8)

6 (7)

 First nations

 

24 (7)

12 (6)

4 (9)

3 (12)

5 (6)

 Other

 

15 (4)

6 (3)

5 (11)

0 (0)

4 (5)

Positive smoking history, n (%)

359

180 (50)

94 (45)

24 (53)

12 (46)

50 (62)

Estimated annual income, $

359

80,135 ± 38,403

81,138 ± 41,542

81,850 ± 40,798

74,125 ± 32,098

78,549 ± 29,996

Baseline lung function

 FVC, %-predicted

350

77 ± 20

79 ± 21

75 ± 23

79 ± 16

70 ± 18

 DLCO, %-predicted

336

56 ± 19

57 ± 19

56 ± 19

56 ± 18

54 ± 17b

 6MWD, metres

279

387 ± 123

395 ± 122

312 ± 116

430 ± 117

374 ± 116

Radiographic pattern, n (%)

359

     

 NSIP Pattern

 

242 (67)

173 (84)

11 (24)

14 (54)

44 (54)

 UIP Pattern

 

46 (13)

17 (8)

17 (38)

2 (8)

10 (12)

 Other/Not specified

 

71 (20)

17 (8)

17 (38)

10 (39)

27 (33)

Mortality, n (%)

357

85 (24)

66 (32)

6 (13)

3 (12)

10 (12)

Median follow up time, y (IQR)

359

4 (2, 8)

5 (2, 8)

3 (1, 5)

3 (1, 8)

3 (1, 5)

  1. Values are reported as mean ± SD unless otherwise stated. SSc systemic sclerosis, RA rheumatoid arthritis, MCTD mixed connective tissue disease, FVC forced vital capacity, DLCO diffusing capacity of lungs for carbon monoxide; 6MWD six-minute walk distance, UIP usual interstitial pneumonia, NSIP non-specific interstitial pneumonia, IQR interquartile range
  2. aPolymyositis (n = 8), dermatomyositis (n = 7), systemic lupus erythematosus (n = 13), primary Sjögren’s syndrome (n = 8), interstitial pneumonia with autoimmune features (n = 14), undifferentiated connective tissue disease (n = 31)
  3. bData not normally distributed; median and interquartile range are 52.0 (45.0, 60.0)